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首页> 外文期刊>Fiziologia: official journal of the Romanian Society of Physiological Sciences >GABAERGIC POTENTIATION OF REDUCED BOWELMOVEMENTS INDUCED WITH ZINC SULPHATE BY BACLOFEN
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GABAERGIC POTENTIATION OF REDUCED BOWELMOVEMENTS INDUCED WITH ZINC SULPHATE BY BACLOFEN

机译：BACLOFEN还原硫酸锌诱导的牛海绵状纤维的厌氧修复

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This study evaluated the influence of orally administered zinc sulphate on bowel movement of rats by the faecal outputand gastrointestinal transit time in the rats. The effects of zinc sulphate on feeding as well as water intake were alsodetermined. The dose of zinc sulphate that yielded the maximal effect was administered alongside baclofen toinvestigate the role of GABA on bowel propulsion. All the three doses of zinc sulphate (1 mgkg-1, 5 mgkg-1 and 10mgkg-1) produced significant reduction (p < 0.05) in total faecal pellets produced in eight hours of study (12.00 ± 0.93,9.17 ± 0.31 and 3.17 ± 0.17) respectively, compared with the control group (15.67 ± 1.38). Also, the three doses ofzinc sulphate produced dose-dependent significant reduction (p < 0.05) in the faecal mass (1.78 ± 0.17, 2.50 ± 0.22and 1.07 ± 0.10) respectively when compared with control group (3.39 ± 0.25).The total transit time of zinc sulphate(10 mgkg-1) treated group (593.8 ± 2.84 min) increased significantly (p < 0.0001, t = 26.98) compared with the controlgroup (251.2 ± 5.48 minutes). Zinc sulphate (5 mgkg-1 and 10 mgkg-1) significantly (p < 0.05) reduced food intake(10.83 ± 0.54 and 12.50 ± 0.51) respectively while (1 mgkg-1) produced increase (p < 0.05) in food intake (22.50 ± 0.56)when compared with the control group (18.33 ± 0.67). Administration of zinc sulphate and zinc + baclofen significantly(p < 0.001, f = 63.9) reduced faecal pellet output (4.80 ± 0.74 and 1.60 ± 0.25) respectively when compared withcontrol (10.2 ± 0.74). The study concluded that zinc sulphate reduced bowel movement in rats stimulating γaminobutyric acid (GABAB) receptors
机译：本研究通过大鼠粪便的排泄量和胃肠道的传递时间来评估口服硫酸锌对大鼠肠蠕动的影响。还确定了硫酸锌对饲料和摄水量的影响。产生最大作用的硫酸锌剂量与巴氯芬合用，以研究GABA在肠推进中的作用。在八小时的研究中，所有三种剂量的硫酸锌（1 mgkg-1、5 mgkg-1和10mgkg-1）都产生了粪便颗粒总量的显着降低（p <0.05）（12.00±0.93、9.17±0.31和3.17） ±0.17），分别与对照组（15.67±1.38）相比。此外，与对照组（3.39±0.25）相比，三剂硫酸锌分别导致粪便质量（1.78±0.17、2.50±0.22和1.07±0.10）的剂量依赖性显着降低（p <0.05）。硫酸锌（10 mgkg-1）治疗组的时间（593.8±2.84分钟）与对照组（251.2±5.48分钟）相比有显着增加（p <0.0001，t = 26.98）。硫酸锌（5 mgkg-1和10 mgkg-1）分别显着（p <0.05）减少了食物摄入（10.83±0.54和12.50±0.51），而（1 mgkg-1）导致食物摄入增加（p <0.05）（与对照组相比（22.50±0.56）（18.33±0.67）。与对照组（10.2±0.74）相比，施用硫酸锌和锌+巴氯芬（p <0.001，f = 63.9）分别降低粪便颗粒产量（4.80±0.74和1.60±0.25）。研究得出结论，硫酸锌减少了刺激γ氨基丁酸（GABAB）受体的大鼠肠蠕动

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