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首页> 外文期刊>Food & Nutrition Research >Increasing doses of fiber do not influence short-term satiety or food intake and are inconsistently linked to gut hormone levels
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Increasing doses of fiber do not influence short-term satiety or food intake and are inconsistently linked to gut hormone levels

机译：纤维剂量的增加不会影响短期的饱腹感或食物摄入，并且与肠道激素水平不一致

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Background: People who eat more fiber often have a lower body weight than people who eat less fiber. The mechanism for this relationship has been explained, in part, by increased satiety, which may occur as a result of changes in appetite-suppressing gut hormone levels, and decreases in food intake at subsequent meals.Objective: We hypothesized that increasing doses of mixed fiber, consumed in muffins for breakfast, would proportionally influence satiety, gut hormone levels, and subsequent food intake.Design: This was a randomized, double-blind, crossover study. Healthy men (n=10) and women (n=10) with a BMI of 24?2 (mean?SEM) participated in this study. Fasting subjects consumed a muffin with 0, 4, 8, or 12 g of mixed fibers and approximately 500 kcal. Visual analog scales rated hunger and satiety for 3 h; blood was drawn to measure ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY3–36 (PYY3–36) at various intervals; and food intake was measured at an ad libitum lunch.Results: Responses to satiety-related questions did not differ among treatments. However, despite lack of differences in satiety, gut hormone levels differed among treatments. Ghrelin was higher after the 12 g fiber dose than after the 4 and 8 g fiber doses. GLP-1 was higher after the 0 g fiber dose than after the 12 and 4 g fiber doses, and PYY3–36 did not differ among fiber doses. Food intake was also indistinguishable among doses.Conclusion: Satiety, gut hormone response, and food intake did not change in a dose-dependent manner after subjects consumed 0, 4, 8, and 12 g of mixed fiber in muffins for breakfast.
机译：背景：吃更多纤维的人的体重通常比吃更少纤维的人低。造成这种关系的部分原因是由于饱腹感的增加，这可能是由于抑制食欲的肠道激素水平的变化以及随后进餐时食物摄入量的减少而引起的。早餐在松饼中食用的纤维素纤维会成比例地影响饱腹感，肠道激素水平和随后的食物摄入。设计：这是一项随机，双盲，交叉研究。 BMI为24？2（平均？SEM）的健康男性（n = 10）和女性（n = 10）参加了这项研究。空腹的受试者吃了一个松饼，其中包含0、4、8或12 g的混合纤维和大约500 kcal。视觉模拟量表对饥饿和饱食的评级为3小时;在不同的时间抽血以测量生长素释放肽，胰高血糖素样肽1（GLP-1）和肽YY3–36（PYY3–36）。结果：随意治疗对饱腹感相关问题的反应没有差异。然而，尽管饱腹感缺乏差异，但治疗之间的肠道激素水平却有所不同。服用12 g纤维后的Ghrelin高于服用4 g和8 g纤维后的Ghrelin。 0克纤维剂量后的GLP-1高于12和4克纤维剂量后的PLP，PYY3–36在不同剂量的纤维之间无差异。结论：受试者在早餐中食用了0、4、8和12 g混合纤维的松饼后，饱腹感，肠激素反应和食物摄入量均未随剂量变化而变化。

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