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首页> 外文期刊>Gynecology, obstetrics & reproductive medicine : >Neonatal Loss Secondary to Third Trimester Chemotherapy for Maternal Breast Cancer
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Neonatal Loss Secondary to Third Trimester Chemotherapy for Maternal Breast Cancer

机译：孕晚期乳腺癌继发于新生儿的新生儿丢失

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Breast cancer is the most common cancer among women with a lifetime risk of 11%. Pregnancy-associated?breast cancer is defined as cancer diagnosed during pregnancy or up to 1 year post partum.?Surgery is the definitive treatment for pregnancy-associated breast cancer. For node-positive patients or?node-negative patients with a tumor greater than 1 cm, a 4 to 6 month course of chemotherapy is the?standard of care. Provided that chemotherapy is not used in the first trimester, it appears to be relatively?safe. A forty-two year old pregnant woman in the third trimester presented with an advanced breast cancer.?Since she had an advanced stage cancer and since she was in the third trimester, she was decided to?be treated with chemotherapy. After three weeks, an emergent cesarean section was performed because?the fetus was in acute distress. On the 20th day, the baby died because of cardiopulmonary arrest. The cause of the death was concluded as perinatal hypoxia secondary to chemotherapy. Even though chemotherapy is shown to be safe during the second and third trimester in many clinical?trials, each case should be handled separately since the assumption of safety may differ in each case.?These pregnants should be observed closer.
机译：乳腺癌是女性中最常见的癌症，终生风险为11％。妊娠相关的乳腺癌定义为在怀孕期间或产后一年内诊断出的癌症。手术是妊娠相关的乳腺癌的最终治疗方法。对于肿瘤大于1 cm的淋巴结阳性患者或淋巴结阴性患者，化疗的4至6个月疗程是标准的治疗方法。如果在头三个月不使用化学疗法，它似乎是相对安全的。妊娠晚期的一名四十二岁孕妇患有晚期乳腺癌。由于她患有晚期癌症，并且由于处于妊娠晚期，因此决定接受化疗。三周后，由于胎儿处于急性窘迫状态，进行了紧急剖宫产。第20天，婴儿因心肺骤停死亡。死亡原因归结为化学疗法继发的围产期低氧。即使在许多临床试验中显示化疗在中期和中期都是安全的，但由于每种情况的安全性假设可能有所不同，因此每种情况都应分开处理。应密切观察这些孕妇。

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