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首页> 外文期刊>Food Science & Nutrition >Nutritional content of selected species of tropical eggplant fruit ( Solanum spp ) diet Attenuates hepatic inflammation in high‐fat fed male Wistar rats induced with streptozotocin
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Nutritional content of selected species of tropical eggplant fruit ( Solanum spp ) diet Attenuates hepatic inflammation in high‐fat fed male Wistar rats induced with streptozotocin

机译：热带茄子果实（Solanum spp）饮食中选定种类的营养成分减轻链脲佐菌素诱导的高脂喂养雄性Wistar大鼠的肝脏炎症

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Tropical Solanum species contains a high level of phenolic acids and flavonoids, which were found to inhibit some key enzymes associated with the incidence of type 2 diabetes in in vitro and in vivo models based on earlier studies. This study was further designed to compare the nutritional properties, glycemic index, and hypolipidemic and the antioxidant effects of three species of tropical eggplant fruit ( Solanum kumba , Solanum aethiopicum, and Solanum gilo ) diet on streptozotocin (STZ)‐induced nephrotoxicity in male Wistar rats. The animal model was subjected to high‐fat diet prior to interperitional administration of streptozotocin (35?mg/kg wt); thereafter, the rats were given supplemented eggplant fruit diet, which lasted for 14?days. Determination of lipid content [triglycerides (TG), low‐density lipoproteins (LDLs), high‐density lipoproteins (HDLs), and total cholesterol (TC)], was assessed, while the liver biomarker enzymes alanine aminotransferase (ALT) alkaline phosphatase (ALP) and aspartate aminotransferase (AST), also endogenous enzymes such as superoxide dismutase (SOD) and catalase (CAT), were determined. Histopathological assessment of inflammation was carried out on kidney while the blood urea nitrogen (BUN), uric acid, and creatinine level on the kidney function were determined. The results showed that the groups with supplemented eggplant diet had significant ( p ??0.05) reduction in lipid profile, decreased leakages of the liver, and kidney function enzymes while there was restoration of depleted endogenous antioxidant enzymes. The inflammatory cells and fat deposit from the histopathological view were reduced. However, S.?kumba had the best nutritional output.
机译：热带茄属物种含有较高水平的酚酸和类黄酮，在较早的研究基础上，在体外和体内模型中发现它们可抑制一些与2型糖尿病的发生有关的关键酶。这项研究的目的是进一步比较三种热带茄子水果（茄子，茄子和茄子）的营养特性，血糖指数，降血脂和抗氧化作用对链脲佐菌素（STZ）诱导的雄性Wistar肾毒性的影响。大鼠。在对链脲佐菌素（35？mg / kg wt）进行间隔期给药之前，对动物模型进行高脂饮食。此后，给大鼠补充茄子水果饮食，持续14天。评估了脂质含量[甘油三酸酯（TG），低密度脂蛋白（LDL），高密度脂蛋白（HDLs）和总胆固醇（TC）]，而肝脏生物标志物酶丙氨酸氨基转移酶（ALT）碱性磷酸酶（确定了ALP）和天冬氨酸转氨酶（AST）以及内源性酶，例如超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。对肾脏进行炎症的组织病理学评估，同时测定肾脏功能的血尿素氮（BUN），尿酸和肌酐水平。结果表明，补充茄子饮食的组的脂质分布显着降低（p <0.05），肝脏和肾脏功能酶的渗漏减少，而内源性抗氧化酶得以恢复。从组织病理学角度看，炎症细胞和脂肪沉积减少了。但是，金葡菌的营养成分最好。

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