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首页> 外文期刊>Food Science & Nutrition >Functional beverage of Garcinia mangostana (mangosteen) enhances plasma antioxidant capacity in healthy adults
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Functional beverage of Garcinia mangostana (mangosteen) enhances plasma antioxidant capacity in healthy adults

机译：藤黄（山竹）功能性饮料可增强健康成年人的血浆抗氧化能力

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AbstractThis study was to investigate the absorption and antioxidant effect of a mangosteen-based functional beverage in humans. The beverage contained mangosteen, aloe vera, green tea, and multivitamins. A randomized, double-blind, placebo-controlled clinical trial was conducted with generally healthy male and female subjects between 18 and 60 years of age. Ten men and 10 women participated in this study. Participants were randomly divided into two groups, treatment and placebo group. Participants received either a daily single dose (245 mL) of the beverage or a placebo. Blood samples were collected from each participant at time points 0, 1, 2, 4, and 6 h. The plasma samples were analyzed by LC/MS for α-mangostin and vitamins B2 and B5. Results indicated that the three analytes were bioavailable, with observed Cmax at around 1 h. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 60% after 1 h, and the elevated antioxidant level lasted at least 6 h. This study demonstrated the bioavailability of α-mangostin and B vitamins from a xanthone-rich beverage and the mechanisms of the increase in plasma antioxidant may be direct effects from antioxidants, enhancement of endogenous antioxidant activity through activation of Nrf2 pathway, and synergism of the antioxidants.
机译：摘要本研究旨在研究山竹果功能饮料在人体中的吸收和抗氧化作用。该饮料包含山竹果，芦荟，绿茶和多种维生素。对年龄在18至60岁之间的总体健康男性和女性受试者进行了一项随机，双盲，安慰剂对照的临床试验。十名男子和十名妇女参加了这项研究。参与者被随机分为两组，即治疗组和安慰剂组。参与者每天接受单次剂量（245毫升）的饮料或安慰剂。在时间点0、1、2、4和6小时从每个参与者收集血液样本。用LC / MS分析血浆样品中α-芒果苷和维生素B 2 和B 5 。结果表明，三种分析物具有生物利用度，观察到的C max 大约在1小时。用氧自由基吸收能力（ORAC）分析测得的抗氧化能力在1小时后增加了60％，并且抗氧化剂水平升高至少持续了6小时。这项研究表明富含a吨酮的饮料中α-芒果，维生素B的生物利用度以及血浆抗氧化剂增加的机制可能是抗氧化剂的直接作用，通过激活Nrf2途径增强内源性抗氧化剂活性以及抗氧化剂的协同作用。

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