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首页> 外文期刊>Folia neuropathologica >Expression of mutated isocitrate dehydrogenase-1 in gliomas is associated with p53 and EGFR expression
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Expression of mutated isocitrate dehydrogenase-1 in gliomas is associated with p53 and EGFR expression

机译：胶质瘤中异柠檬酸脱氢酶-1的表达与p53和EGFR的表达有关

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Gliomas are the most common primary brain tumours. Several independent studies have shown that isocitrate dehydrogenase 1 (IDH1) mutation in diffuse gliomas is associated with a more favourable patient outcome. The aim of this study was to evaluate the prognostic relevance of an antibody specifically detecting the R132H point mutation of IDH1 in tissue sections in a large series of human gliomas. Surgical specimens of 220 consecutive patients with infiltrative low and high-grade gliomas were included in this retrospective study. In multivariate analysis, IDH expression did not reach significance (p = 0.122) in regard to prognosis, in contrast to WHO grade and age at time of surgery (p
机译：神经胶质瘤是最常见的原发性脑肿瘤。几项独立研究表明，弥漫性神经胶质瘤中的异柠檬酸脱氢酶1（IDH1）突变与更有利的患者预后相关。这项研究的目的是评估特异性检测大量人类神经胶质瘤组织切片中IDH1的R132H点突变的抗体的预后相关性。这项回顾性研究包括220例连续的浸润性低，高级别神经胶质瘤患者的手术标本。在多变量分析中，IDH表达在预后方面未达到显着性（p = 0.122），而与WHO手术时的世卫组织等级和年龄相反（p

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