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首页> 外文期刊>Folia histochemica et cytobiologica >The immunoreactivity of TGF-b1 in non-alcoholic fatty liver disease
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The immunoreactivity of TGF-b1 in non-alcoholic fatty liver disease

机译：TGF-b1在非酒精性脂肪肝中的免疫反应性

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Introduction. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which becomes a rapidly growing health problem in the Western countries. The development of the disease is most often connected to obesity. NAFLD is also considered as the hepatic manifestation of metabolic syndrome. Transforming growth factor b1 (TGF-b1) plays an important role in the pathogenesis of liver fibrosis, being involved in activation of hepatic stellate cells, stimulation of collagen gene transcription, and suppression of matrix metalloproteinase expression. The objective of the study was to evaluate by immunohistochemistry the expression of TGF-b1 in the liver tissue of NAFLD patients and correlate it with anthropometric, biochemical and routine histological parameters. Material and methods. The study group consisted of 48 patients with diagnosed NAFLD. Liver steatosis, NAFLD Activity Score (NAS) and METAVIR score of fibrosis were evaluated in liver biopsies. The immunoreactivity of TGF-b1 was evaluated semi-quantitatively separately in portal, septal, lobular hepatocytic and lobular sinusoidal liver compartments. The results were analyzed in regard to patients’ clinical and biochemical parameters. Results. Neither steatosis nor NAS correlated with TGF-b1 expression in any liver compartment, whereas METAVIR score of fibrosis was associated with increased immunoreactivity of TGF-b1 in most of the studied liver compartments. TGF-b1 immunoreactivity showed positive correlation with patients’ age and its expression in septal compartment disclosed positive correlation with body mass index, and waist and hip circumference. Hyaluronic acid serum level was positively and iron concentration was negatively associated with TGF-b1 expression in the selected consecutive liver compartments. Conclusions. The immunohistochemical expression of TGF-b1 may be complementary to routine methods of liver fibrosis evaluation.
机译：介绍。非酒精性脂肪性肝病（NAFLD）是一种常见的慢性肝病，在西方国家中，这种疾病正迅速发展为健康问题。疾病的发展通常与肥胖有关。 NAFLD也被认为是代谢综合征的肝脏表现。转化生长因子b1（TGF-b1）在肝纤维化的发病机理中起重要作用，参与肝星状细胞的活化，刺激胶原基因转录和抑制基质金属蛋白酶的表达。该研究的目的是通过免疫组织化学评估NAFLD患者肝脏组织中TGF-b1的表达，并将其与人体测量学，生化和常规组织学参数相关联。材料与方法。研究组包括48位被诊断为NAFLD的患者。在肝活检中评估肝脂肪变性，NAFLD活性评分（NAS）和纤维化的METAVIR评分。 TGF-b1的免疫反应性分别在门静脉，隔中，小叶肝细胞和小叶正弦肝区室中半定量评估。分析了有关患者临床和生化指标的结果。结果。脂肪变性和NAS均不与任何肝区室中的TGF-b1表达相关，而在大多数研究的肝区室中，纤维化的METAVIR评分与TGF-b1的免疫反应性增加相关。 TGF-b1免疫反应性与患者年龄呈正相关，其在隔室的表达与体重指数以及腰围和臀围呈正相关。在选定的连续肝区室中，透明质酸血清水平与TGF-b1表达呈负相关。结论。 TGF-b1的免疫组织化学表达可能是常规肝纤维化评估方法的补充。

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