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首页> 外文期刊>Fisheries and Aquatic Sciences >An Anti-inflammatory Peptide Isolated from Seahorse Hippocampus kuda bleeler Inhibits the Invasive Potential of MG-63 Osteosarcoma Cells
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An Anti-inflammatory Peptide Isolated from Seahorse Hippocampus kuda bleeler Inhibits the Invasive Potential of MG-63 Osteosarcoma Cells

机译：从海马海马kuuda bleerer分离的抗炎肽抑制MG-63骨肉瘤细胞的侵袭潜力。

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Osteosarcoma is the most common primary malignancy of bone, and patients often develop pulmonary metastasis. The mechanisms underlying osteosarcoma metastasis remain to be elucidated. Recently, anti-inflammatory agents were shown to be useful in the treatment of tumor progression. We previously isolated a natural anti-inflammatory peptide from the seahorse Hippocampus kuda bleeler. Here, we examined the antitumor metastatic activity of this peptide and investigated its mechanism. The peptide significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced invasive migration of human osteosarcoma MG-63 cells. Its inhibitory effect on invasive migration was associated with reduced expression of matrix metalloproteinases (MMP1 and MMP2). In addition, TPA stimulation increased intracellular reactive oxygen species (ROS) generation and small GTPase Rac1 expression, whereas the peptide decreased ROS generation and Rac1 activation. Taken together, these results suggest that the peptide inhibits invasive migration of MG-63 osteosarcoma cells by inhibiting MMP1 and MMP2 expression through downregulation of Rac1-ROS signaling.
机译：骨肉瘤是最常见的原发性骨恶性肿瘤，患者经常发生肺转移。骨肉瘤转移的潜在机制仍有待阐明。最近，抗炎药已显示可用于治疗肿瘤进展。我们先前从海马海马kuda漂白剂中分离出天然抗炎肽。在这里，我们检查了该肽的抗肿瘤转移活性，并研究了其机制。该肽显着抑制了12-O-十四烷酰佛波醇13-乙酸盐（TPA）诱导的人骨肉瘤MG-63细胞的侵袭性迁移。它对侵袭性迁移的抑制作用与基质金属蛋白酶（MMP1和MMP2）的表达降低有关。此外，TPA刺激增加了细胞内活性氧（ROS）的生成和GTPase Rac1的小表达，而该肽减少了ROS的生成和Rac1的激活。两者合计，这些结果表明，该肽通过下调Rac1-ROS信号传导抑制MMP1和MMP2表达，从而抑制MG-63骨肉瘤细胞的侵袭性迁移。

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