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Antioxidant and Antibacterial Activities of Chitosan-Phloroglucinol Conjugate

机译：壳聚糖-间苯三酚缀合物的抗氧化和抗菌活性

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摘要

In an effort to develop biopolymer-based antioxidant and antibacterial materials, a chitosan-phloroglucinol conjugate was prepared and cellular antioxidant activity and minimum inhibitory concentration against foodborne pathogens and methicillin-resistant Staphylococcus aureus (MRSA) evaluated. The chitosan-phloroglucinol conjugate showed higher antioxidant activities than the unmodified chitosan (P < 0.05). The chitosan-phloroglucinol conjugate showed 62.29% reactive oxygen species scavenging activity, 56.11% lipid peroxidation inhibition activity, and 2.21-fold increase of glutathione expression in mouse macrophage cells. Additionally, the chitosan-phloroglucinol conjugate exhibited higher antibacterial activities than the unmodified chitosan, and the chitosan-phloroglucinol conjugate showed fourfold higher antibacterial activities against MRSA and clinical isolates and twofold higher activities against foodborne pathogens compared to the unmodified chitosan.
机译：为了开发基于生物聚合物的抗氧化剂和抗菌材料，制备了壳聚糖-间苯三酚共轭物，并评估了细胞抗氧化活性以及对食源性病原体和耐甲氧西林金黄色葡萄球菌（MRSA）的最低抑制浓度。壳聚糖-间苯三酚共轭物显示出比未修饰的壳聚糖更高的抗氧化活性（P <0.05）。壳聚糖-间苯三酚偶联物在小鼠巨噬细胞中显示出62.29％的活性氧清除活性，56.11％的脂质过氧化抑制活性以及谷胱甘肽表达的2.21倍增加。另外，与未修饰的壳聚糖相比，壳聚糖-间苯三酚缀合物显示出比未修饰的壳聚糖更高的抗菌活性，并且壳聚糖-间苯三酚缀合物对MRSA和临床分离株显示出四倍更高的抗菌活性和对食源性病原体的两倍高活性。

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