• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Endocrinology >Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands
【24h】

Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands

机译：啮齿动物胰腺生物学的知识空白：将人类多能干细胞衍生的胰腺β细胞带入我们自己的手中

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy. Traditionally, knowledge gathered from rodents is extended to human pancreas developmental biology research involving human pluripotent stem cells (hPSCs). While much has been learnt from rodent pancreas biology in the early steps toward Pdx1~(+)pancreatic progenitors, much less is known about the transition toward Ngn3~(+)pancreatic endocrine progenitors. Essentially, the later steps of pancreatic β cell development and maturation remain elusive to date. As a result, the most recent advances in the stem cell and diabetes field have relied upon combinatorial testing of numerous growth factors and chemical compounds in an arbitrary trial-and-error fashion to derive mature and functional human pancreatic β cells from hPSCs. Although this hit-or-miss approach appears to have made some headway in maturing human pancreatic β cells in vitro , its underlying biology is vaguely understood. Therefore, in this mini-review, we discuss some of these late-stage signaling pathways that are involved in human pancreatic β cell differentiation and highlight our current understanding of their relevance in rodent pancreas biology. Our efforts here unravel several novel signaling pathways that can be further studied to shed light on unexplored aspects of rodent pancreas biology. New investigations into these signaling pathways are expected to advance our knowledge in human pancreas developmental biology and to aid in the translation of stem cell biology in the context of diabetes treatments.
机译：在干细胞生物学和糖尿病领域，我们和其他研究者寻求衍生出成熟且功能正常的人胰腺β细胞用于疾病建模和细胞替代疗法。传统上，从啮齿类动物中收集的知识被扩展到涉及人类多能干细胞（hPSC）的人类胰腺发育生物学研究。虽然从啮齿类动物胰腺生物学向Pdx1〜（+）胰腺祖细胞的早期了解到很多，但对向Ngn3〜（+）胰腺内分泌祖细胞过渡的了解却很少。从本质上讲，迄今为止胰岛β细胞发育和成熟的后期步骤仍然难以捉摸。结果，干细胞和糖尿病领域的最新进展依赖于以任意试验和错误方式对多种生长因子和化合物进行组合测试，以从hPSC衍生出成熟且功能正常的人胰腺β细胞。尽管这种命中注定的方法似乎在体外使人胰岛β细胞成熟方面取得了一些进展，但其潜在的生物学知识尚不清楚。因此，在本微型综述中，我们讨论了与人类胰腺β细胞分化有关的一些晚期信号通路，并强调了我们目前对它们在啮齿动物胰腺生物学中的相关性的理解。我们在这里的努力揭示了几种新颖的信号通路，可以进一步研究以阐明啮齿动物胰腺生物学的未探索方面。这些信号通路的新研究有望增进我们在人类胰腺发育生物学中的知识，并在糖尿病治疗的背景下协助干细胞生物学的翻译。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号