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首页> 外文期刊>Fisheries and Aquatic Sciences >Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice
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Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice

机译：Ecklonia cava的睡眠促进作用：乙醇提取物可促进C57BL / 6N小鼠的非快速眼动睡眠

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摘要

We investigated the effects of Ecklonia cava ethanol extract (ECE) on sleep architecture and sleep profiles. ECE was orally administered at a dose of 100, 250, or 500 mg/kg to C57BL/6N mice and its effects were measured by recording electroencephalogram (EEG) and electromyogram. Administration of ECE (250 and 500 mg/kg) significantly induced non-rapid eye movement sleep (NREMS) without affecting rapid eye movement sleep. The increase in NREMS by ECE (500 mg/kg) was significant (P < 0.05) during the first 2 h after administration. In addition, ECE had no effect on EEG power density (an indicator of sleep quality) in NREMS. These results suggest that ECE induces NREMS in a manner similar to physiological sleep.
机译：我们调查了Ecklonia卡瓦乙醇提取物（ECE）对睡眠结构和睡眠状况的影响。以100、250或500 mg / kg的剂量对C57BL / 6N小鼠口服ECE，并通过记录脑电图（EEG）和肌电图测量其效果。服用ECE（250和500 mg / kg）可显着诱导非快速眼动睡眠（NREMS），而不会影响快速眼动睡眠。 ECE（500 mg / kg）使NREMS的增加在给药后的前2小时内显着（P <0.05）。此外，ECE对NREMS中​​的EEG功率密度（睡眠质量指标）没有影响。这些结果表明，ECE以类似于生理睡眠的方式诱导NREMS。

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