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首页> 外文期刊>Frontiers in Immunology >Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis
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Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis

机译：吸烟对胃肠道炎症的影响：克罗恩病和溃疡性结肠炎的对立作用

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摘要

Cigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn’s disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of ulcerative colitis (UC). UC and CD represent the two most important conditions of inflammatory bowel diseases, and share several clinical features. The opposite effects of smoking on these two conditions have been a topic of great interest in the last 30 years, and has not yet been clarified. In this review, we summarize the most important and well-understood effects of smoking in the gastrointestinal tract; and particularly, in intestinal inflammation, discussing available studies that have addressed the causes that would explain the opposite effects of smoking in CD and UC.
机译：吸烟是胃肠道疾病的主要危险因素，例如消化性溃疡，克罗恩病（CD）和几种癌症。为解释吸烟在这些疾病中的作用而提出的机制包括粘膜损伤，肠道冲洗改变和粘膜免疫反应受损。矛盾的是，吸烟是溃疡性结肠炎（UC）发生和发展的保护因素。 UC和CD代表炎症性肠病的两个最重要条件，并具有一些临床特征。在过去的30年中，吸烟对这两种情况的相反影响一直是人们非常感兴趣的话题，并且尚未弄清。在这篇综述中，我们总结了吸烟在胃肠道中最重要和最容易理解的作用。尤其是在肠道炎症中，讨论可以解决导致CD和UC吸烟产生相反作用的原因的现有研究。

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