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首页> 外文期刊>Gastroenterology research and practice >Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease—Is There a Link?
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Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease—Is There a Link?

机译：慢性肾脏病和非酒精性脂肪肝疾病—有联系吗？

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Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD. The best confirmation of this pathogenic link is hypertensive and diabetic nephropathy as the main causes of CKD. Furthermore, the possible link between NAFLD and CKD has also attracted research interest and recent data suggest an association between these two conditions. These findings have fuelled concerns that NAFLD may be a new and added risk factor for the development and progression of CKD. NAFLD and CKD share some important cardiometabolic risk factors and possible common pathophysiological mechanisms, and both are linked to an increased risk of incident CVD events. Therefore, common factors underlying the pathogenesis of NAFLD and CKD may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver.
机译：近年来的研究已导致人们认识到非酒精性脂肪肝疾病（NAFLD）的重要性及其与代谢综合征（MS）的关系。这引起了人们对NAFLD对不良心血管疾病（CVD）预后的潜在预后价值的日益增长的兴趣。另一方面，寻找慢性肾脏病（CKD）发生和发展的新危险因素非常重要。越来越多的证据表明，MS是CKD发病机理的重要因素。这种致病联系的最好确认是高血压和糖尿病性肾病是CKD的主要原因。此外，NAFLD和CKD之间的可能联系也引起了研究兴趣，最近的数据表明这两种情况之间存在关联。这些发现激起了人们对NAFLD可能是CKD发生和发展的新的和增加的危险因素的担忧。 NAFLD和CKD具有一些重要的心脏代谢危险因素和可能的常见病理生理机制，并且两者都与发生CVD事件的风险增加有关。因此，NAFLD和CKD发病机理的共同因素可能是胰岛素抵抗，氧化应激，肾素-血管紧张素系统的活化以及脂肪变性和发炎的肝脏不适当分泌炎性细胞因子。

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