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首页> 外文期刊>Frontiers in Immunology >Anaphylaxis in Elderly Patients—Data From the European Anaphylaxis Registry
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Anaphylaxis in Elderly Patients—Data From the European Anaphylaxis Registry

机译：老年患者的过敏反应—来自欧洲过敏反应注册中心的数据

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Background: Elicitors and symptoms of anaphylaxis are age dependent. However, little is known about typical features of anaphylaxis in patients aged 65 years or more. Methods: The data from the Network for Online Registration of Anaphylaxis (NORA) considering patients aged ≥65 (elderly) in comparison to data from adults (18–64 years) regarding elicitors, symptoms, comorbidities, and treatment measures were analyzed. Results: We identified 1,123 elderly anaphylactic patients. Insect venoms were the most frequent elicitor in this group ( p & 0.001), followed by drugs like analgesics and antibiotics. Food allergens elicited less frequently anaphylaxis ( p & 0.001). Skin symptoms occurred less frequently in elderly patients (77%, p & 0.001). The clinical symptoms were more severe in the elderly (51% experiencing grade III/IV reactions), in particular when skin symptoms ( p & 0.001) were absent. Most strikingly, a loss of consciousness (33%, p & 0.001) and preexisting cardiovascular comorbidity (59%, p & 0.001) were more prevalent in the elderly. Finally, adrenaline was used in 30% of the elderly (vs. 26% in the comparator group, p & 0.001) and hospitalization was more often required (60 vs. 50%, p & 0.001). Discussion and Conclusion: Anaphylaxis in the elderly is often caused by insect venoms and drugs. These patients suffer more often from cardiovascular symptoms, receive more frequently adrenaline and require more often hospitalization. The data indicate that anaphylaxis in the elderly tends to be more frequently life threatening and patients require intensified medical intervention. The data support the need to recognize anaphylaxis in this patient group, which is prone to be at a higher risk for a fatal outcome.
机译：背景：引发过敏反应的症状和症状取决于年龄。但是，对于65岁以上的患者过敏反应的典型特征知之甚少。方法：分析了年龄大于等于65岁（老年人）的过敏反应在线注册网络（NORA）的数据，与成人（18-64岁）的诱发因素，症状，合并症和治疗措施进行了比较。结果：我们确定了1,123例老年过敏症患者。昆虫毒液是该组中最常见的引发剂（p ＜0.001），其次是止痛药和抗生素之类的药物。食物变应原引起的过敏反应较少（p ＜0.001）。在老年患者中皮肤症状发生的频率较低（77％，p ＜0.001）。老年人的临床症状更为严重（51％经历III / IV级反应），尤其是在没有皮肤症状时（p <0.001）。最显着的是，老年人的意识丧失（33％，p ＜0.001）和先前存在的心血管合并症（59％，p ＜0.001）更普遍。最后，肾上腺素用于30％的老年人（对比组中为26％，p ＜0.001），并且更需要住院治疗（60对50％，p ＜0.001）。讨论与结论：老年人的过敏反应通常是由昆虫的毒液和药物引起的。这些患者更常患有心血管症状，接受肾上腺素的频率更高，并且需要住院的频率更高。数据表明，老年人的过敏反应往往会威胁生命，并且患者需要加强医疗干预。数据支持需要识别该患者组中的过敏反应，而致命风险倾向于更高。

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