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首页> 外文期刊>Frontiers in Immunology >Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters
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Candidate SNP Markers of Gender-Biased Autoimmune Complications of Monogenic Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

机译：TATA结合蛋白对人类基因启动子的亲和力发生重大变化，从而预测了性别歧视性单基因疾病的自身SNP候选候选SNP标记。

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Some variations of human genome [for example, single nucleotide polymorphisms (SNPs)] are markers of hereditary diseases and drug responses. Analysis of them can help to improve treatment. Computer-based analysis of millions of SNPs in the 1000 Genomes project makes a search for SNP markers more targeted. Here, we combined two computer-based approaches: DNA sequence analysis and keyword search in databases. In the binding sites for TATA-binding protein (TBP) in human gene promoters, we found candidate SNP markers of gender-biased autoimmune diseases, including rs1143627 [cachexia in rheumatoid arthritis (double prevalence among women)]; rs11557611 [demyelinating diseases (thrice more prevalent among young white women than among non-white individuals)]; rs17231520 and rs569033466 [both: atherosclerosis comorbid with related diseases (double prevalence among women)]; rs563763767 [Hughes syndrome-related thrombosis (lethal during pregnancy)]; rs2814778 [autoimmune diseases (excluding multiple sclerosis and rheumatoid arthritis) underlying hypergammaglobulinemia in women]; rs72661131 and rs562962093 (both: preterm delivery in pregnant diabetic women); and rs35518301, rs34166473, rs34500389, rs33981098, rs33980857, rs397509430, rs34598529, rs33931746, rs281864525, and rs63750953 (all: autoimmune diseases underlying hypergammaglobulinemia in women). Validation of these predicted candidate SNP markers using the clinical standards may advance personalized medicine.
机译：人类基因组的某些变异[例如，单核苷酸多态性（SNP）]是遗传性疾病和药物反应的标志。对它们进行分析可以帮助改善治疗。对1000个基因组项目中数百万个SNP的基于计算机的分析使搜索SNP标记更具针对性。在这里，我们结合了两种基于计算机的方法：DNA序列分析和数据库中的关键字搜索。在人类基因启动子中TATA结合蛋白（TBP）的结合位点中，我们发现了性别偏向的自身免疫性疾病的候选SNP标记，包括rs1143627 [类风湿性关节炎的恶病质（女性双发）。 rs11557611 [脱髓鞘疾病（年轻的白人女性患病率比非白人个体高三倍）]; rs17231520和rs569033466 [两者：动脉粥样硬化合并相关疾病（妇女中双患病率）]; rs563763767 [休斯综合症相关的血栓形成（怀孕期间致命）]; rs2814778 [妇女高免疫球蛋白血症潜在的自身免疫性疾病（不包括多发性硬化症和类风湿性关节炎）]; rs72661131和rs562962093（均：糖尿病孕妇的早产）;和rs35518301，rs34166473，rs34500389，rs33981098，rs33980857，rs397509430，rs34598529，rs33931746，rs281864525和rs63750953（全部：女性免疫球蛋白高血症的自身免疫性疾病）。使用临床标准验证这些预测的候选SNP标记可能会促进个性化医学。

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