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首页> 外文期刊>Frontiers in Public Health >Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria
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Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria

机译：关于可行但不可培养的病原细菌的最新观点

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Under stress conditions, many species of bacteria enter into starvation mode of metabolism or a physiologically viable but non-culturable (VBNC) state. Several human pathogenic bacteria have been reported to enter into the VBNC state under these conditions. The pathogenic VBNC bacteria cannot be grown using conventional culture media, although they continue to retain their viability and express their virulence. Though there have been debates on the VBNC concept in the past, several molecular studies have shown that not only can the VBNC state be induced under in vitro conditions but also that resuscitation from this state is possible under appropriate conditions. The most notable advance in resuscitating VBNC bacteria is the discovery of resuscitation-promoting factor (Rpf), which is a bacterial cytokines found in both Gram-positive and Gram-negative organisms. VBNC state is a survival strategy adopted by the bacteria, which has important implication in several fields, including environmental monitoring, food technology, and infectious disease management; and hence it is important to investigate the association of bacterial pathogens under VBNC state and the water/foodborne outbreaks. In this review, we describe various aspects of VBNC bacteria, which include their proteomic and genetic profiles under the VBNC state, conditions of resuscitation, methods of detection, antibiotic resistance, and observations on Rpf.
机译：在压力条件下，许多细菌进入饥饿的新陈代谢模式或生理上可行但不可培养的状态。据报道，在这些条件下，几种人类致病细菌进入VBNC状态。尽管病原性VBNC细菌继续保持其生存能力并表达其毒力，但无法使用常规培养基进行生长。尽管过去有关VBNC概念的争论一直存在，但一些分子研究表明，不仅可以在体外条件下诱导VBNC状态，而且在适当条件下也可以从该状态复苏。复苏VBNC细菌最显着的进展是复苏促进因子（Rpf）的发现，它是在革兰氏阳性和革兰氏阴性生物中都发现的细菌细胞因子。 VBNC状态是细菌采取的一种生存策略，在环境监测，食品技术和传染病管理等多个领域具有重要意义。因此，调查VBNC状态下细菌性病原体与水/食源性疾病暴发之间的关联非常重要。在这篇综述中，我们描述了VBNC细菌的各个方面，包括其在VBNC状态下的蛋白质组学和遗传概况，复苏条件，检测方法，抗生素耐药性以及对Rpf的观察。

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