• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Public Health >The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities
【24h】

The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities

机译：西班牙裔和拉丁美洲裔2型糖尿病的遗传基础：挑战和机遇

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Type 2 diabetes (T2D) affects 415 million people worldwide, and has a much higher prevalence in Hispanics (16.9%), compared to non-Hispanic whites (10.2%). Genome-wide association studies and whole-genome and whole-exome sequencing studies have discovered more than 100 genetic regions associated with modified risk for T2D. However, the identified genetic factors explain a very small fraction of the estimated heritability. Until recently, little attention has been put in studying other non European populations that suffer from a higher burden of T2D, such as Hispanics/Latinos. In the past few years, genetic studies in Hispanic populations have started to provide new insights into the genetic architecture of T2D in this ancestry group. Of note, several genetic variants that are absent or very rare in non-Hispanic populations but more common in Hispanics have shown from moderate to strong association with T2D and have provided new insights into the biology of T2D, which may be ultimately useful for developing novel therapeutic strategies applicable to all populations. Studying diverse populations can also improve the ability to find the causal variants in known T2D loci by a multi-ancestry fine-mapping approach, which leverages the different patterns of linkage disequilibrium between the causal and the ascertained genetic variants. In this mini-review, we summarize the main genetic findings discovered in Hispanics and discuss the limitations and challenges of performing genetic studies in these populations. Finally, we present possible next steps to make studies in Latino populations more valuable in providing a deeper understanding of T2D and anticipate their future application to the development of predictive and preventive medicine and personalized therapies.
机译：与非西班牙裔白人（10.2％）相比，全球2亿1千5百万人患有2型糖尿病（T2D），西班牙裔（16.9％）患病率更高。全基因组关联研究以及全基因组和全外显子组测序研究发现了100多个与改变的T2D风险相关的遗传区域。但是，确定的遗传因素仅占估计遗传力的很小一部分。直到最近，对西班牙人/拉丁裔等遭受T2D负担较高的其他非欧洲人口的研究仍很少引起关注。在过去的几年中，西班牙裔人群的遗传研究开始为这个血统的人群提供有关T2D遗传结构的新见解。值得注意的是，在非西班牙裔人群中不存在或非常罕见但在西班牙裔中更常见的几种遗传变异与T2D的关联从中等到强烈，为T2D的生物学提供了新的见解，这些变异最终可能对开发新型适用于所有人群的治疗策略。研究多种种群还可以通过多谱系精细映射方法提高在已知T2D基因座中查找因果变异的能力，该方法利用了因果变异和确定的遗传变异之间连锁不平衡的不同模式。在这份小型回顾中，我们总结了西班牙裔发现的主要遗传发现，并讨论了在这些人群中进行遗传研究的局限性和挑战。最后，我们提出了可能的下一步措施，以使对拉丁裔人群的研究更有价值，从而可以更深入地了解T2D，并预测其在预测性和预防性医学以及个性化疗法的发展中的未来应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号