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首页> 外文期刊>Frontiers in Public Health >Diminution of Heart Rate Variability in Bipolar Depression
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Diminution of Heart Rate Variability in Bipolar Depression

机译：双相抑郁症患者心率变异性的降低

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Autonomic nervous system (ANS) dysregulation in depression is associated with symptoms associated with the ANS. The beat-to-beat pattern of heart rate defined as heart rate variability (HRV) provides a noninvasive portal to ANS function and has been proposed to represent a means of quantifying resting vagal tone. We quantified HRV in bipolar depressed (BDD) patients as a measure of ANS dysregulation seeking to establish HRV as a potential diagnostic and prognostic biomarker for treatment outcome. Forty-seven BDD patients were enrolled. They were randomized to receive either escitalopram–celecoxib or escitalopram-placebo over 8 weeks in a double-blind study design. Thirty-five patients completed the HRV studies. Thirty-six healthy subjects served as controls. HRV was assessed at pretreatment and end of study and compared with that of controls. HRV was quantified and corrected for artifacts using an algorithm that incorporates time and frequency domains to address non-stationarity of the beat-to-beat heart rate pattern. Baseline high frequency-HRV (i.e., respiratory sinus arrhythmia) was lower in BDD patients than controls, although the difference did not reach significance. Baseline low-frequency HRV was significantly lower in BDD patients (ln4.20) than controls (ln = 5.50) (p < 0.01). Baseline heart period was significantly shorter (i.e., faster heart rate) in BDD patients than controls. No significant change in HRV parameters were detected over the course of the study with either treatment. These findings suggest that components of HRV may be diminished in BDD patients.
机译：抑郁中的自主神经系统（ANS）失调与ANS相关的症状有关。定义为心率变异性（HRV）的心率逐次跳动模式为ANS功能提供了一种非侵入性门户，并已被提出代表量化静息迷走神经张力的一种手段。我们对双相抑郁症（BDD）患者的HRV进行量化，以作为ANS失调的一种措施，以期将HRV建立为治疗结果的潜在诊断和预后生物标志物。招募了47名BDD患者。在双盲研究设计中，他们被随机分配接受艾司西酞普兰-塞来昔布或艾司西酞普兰-安慰剂8周以上。 35名患者完成了HRV研究。 36名健康受试者作为对照。在治疗前和研究结束时评估HRV，并与对照组进行比较。使用合并了时域和频域的算法对HRV进行了量化，并针对伪影进行了校正，以解决逐次跳动心率模式的非平稳性。尽管BDD患者的基线高频-HRV（即呼吸窦性心律不齐）低于对照组，但差异并未达到显着水平。 BDD患者（ln4.20）的基线低频HRV显着低于对照组（ln = 5.50）（p <0.01）。 BDD患者的基线心脏周期明显短于对照组（即更快的心率）。在任一种治疗的研究过程中，均未发现HRV参数有明显变化。这些发现表明，在BDD患者中HRV的成分可能减少。

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