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首页> 外文期刊>Functional Foods In Health And Disease >Beneficial effects of maltobionic acid on bone density in healthy Japanese adult women: A randomized double-blind placebo-controlled study
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Beneficial effects of maltobionic acid on bone density in healthy Japanese adult women: A randomized double-blind placebo-controlled study

机译：麦芽糖酸对健康日本成年女性骨密度的有益影响：一项随机双盲安慰剂对照研究

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Background: Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk, with a higher incidence in post-menopausal women. This study aimed to evaluate the safety and efficacy of long-term ingestion of maltobionic acid on BMD in healthy Japanese women.Methods: A randomized, double-blind, placebo-controlled, parallel-group study was conducted from February to December 2018. Thirty-eight healthy Japanese women aged 50–69 years who were at least 1 year past the onset of natural menopause were allocated to two groups (19 in each group) using a computerized random-number generator: one in which participants ingested 7 g of corn syrup containing maltobionic acid and another in which participants ingested 7 g of placebo (maltose syrup) per day for 24 weeks. BMD and bone metabolism parameters were measured dual-energy X-ray absorptiometry (DEXA) method and a peripheral blood test, respectively, whereas safety was evaluated via a physical examination, peripheral blood test, urinalysis, assessment of subjective symptoms, and a medical questionnaire.Results: Of the 38 subjects, one subject discontinued the study halfway and 14 were excluded before the efficacy analysis because of conflicts with control criteria. Thus, the final study population was 23 subjects (10 in the Test food group and 13 in the Placebo group). There were no adverse events related to consumption of the test food. Consumption of corn syrup solids containing maltobionic acid was maintained during the intervention period, and BMD, bone mineral content, and young adult mean values were found to be improved (P < 0.05). No safety concerns were observed during the intervention period.Conclusion: These results indicate that the consumption of maltobionic acid may contribute to the prevention of osteoporosis.Trial registration: UMIN-CTR ID: UMIN000031489; Foundation: San-ei Sucrochemical Co., Ltd.
机译：背景：骨质疏松症的特征在于骨矿物质密度（BMD）降低和骨折风险增加，绝经后妇女的发生率更高。这项研究旨在评估长期摄入麦芽糖酸对健康的日本女性的BMD的安全性和有效性。方法：于2018年2月至12月进行了一项随机，双盲，安慰剂对照，平行组研究。使用计算机随机数发生器将八位健康的日本女性（年龄在50-69岁之间，至少在自然更年期开始后至少一年）分配为两组（每组19位）：一组参与者摄入7克玉米含麦芽糖酸的糖浆，另一种参与者在24周内每天摄入7克安慰剂（麦芽糖浆）。 BMD和骨代谢参数分别通过双能X线吸收法（DEXA）和外周血测试测量，而安全性通过体格检查，外周血测试，尿液分析，主观症状评估和医疗问卷进行评估结果：在38名受试者中，一名受试者中途中断研究，由于与对照标准相抵触，在进行功效分析之前排除了14名受试者。因此，最终的研究人群为23名受试者（测试食品组为10名，安慰剂组为13名）。没有与食用试验食品有关的不良事件。干预期间维持了含有麦芽糖酸的玉米糖浆固体的消耗，并且发现BMD，骨矿物质含量和年轻成年人的平均值得到改善（P <0.05）。干预期间未观察到安全问题。结论：这些结果表明，食用麦芽糖酸可能有助于预防骨质疏松症。试验注册：UMIN-CTR ID：UMIN000031489;成立：三荣超化学有限公司

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