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首页> 外文期刊>Frontiers in Aging Neuroscience >Incidence of Mild Cognitive Impairment and Dementia in Parkinson’s Disease: The Parkinson’s Disease Cognitive Impairment Study
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Incidence of Mild Cognitive Impairment and Dementia in Parkinson’s Disease: The Parkinson’s Disease Cognitive Impairment Study

机译：帕金森氏病轻度认知障碍和痴呆的发病率：帕金森氏病认知障碍研究

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Background: Cognitive impairment in Parkinson’s disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7–262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15–0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7–58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3–202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60–21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.
机译：背景：帕金森氏病（PD）的认知障碍包括从轻度认知障碍（PD-MCI）到PD痴呆症（PDD）的频谱。本研究的主要目的是评估PD-MCI的发生率，其发展为痴呆的速度，并确定预测PD患者认知障碍的人口统计学和临床​​特征。方法：回顾性研究了来自大型医院队列的PD患者，他们至少接受了两次全面的神经心理学评估。 PD-MCI和PDD根据运动障碍学会标准诊断。估计PD-MCI和PDD的发生率。使用Cox比例风险模型评估了预测PD-MCI和痴呆的临床和人口统计学因素。结果：在139名登记的PD患者中，有84名具有正常认知（PD-NC）分类，而55名（39.6％）在基线时达到了PD-MCI的诊断。随访时（平均随访23.5±10.3个月），在基线时发展为MCI的84例PD-NC中有28例（33.3％）转化为PDD，其中4例（4.8％）转化为PDD。 PD-MCI的发生率为184.0 / 1000 pyar（95％CI 124.7–262.3）。在多变量分析中，观察到随访与教育和MCI发展之间存在负相关性（HR 0.37，95％CI 0.15-0.89; p = 0.03）。痴呆的发生率为24.3 / 1000 pyar（95％CI 7.7-58.5）。在基线时有55名PD-MCI患者中，有14名（25.4％）转换为PDD，发生率为123.5 / 1000 pyar（95％CI 70.3–202.2）。在基线时患有MCI的PD患者中发现PDD的风险增加了五倍（RR 5.09，95％CI 1.60-21.4）。结论：我们的研究支持PD-MCI在预测PDD中的相关作用，并强调了教育在降低认知障碍风险中的重要性。

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