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首页> 外文期刊>Frontiers in Neuropharmacology >Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder
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Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder

机译：创伤后应激障碍大鼠模型中的空间记忆受损和习惯记忆增强

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High levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to determine whether these memory systems may be similarly affected in an animal model of post-traumatic stress disorder (PTSD). Sprague-Dawley rats were subjected to a “single-prolonged stress” (SPS) procedure and one week later received training in one of two distinct versions of the plus-maze: a hippocampus-dependent place learning task or a DLS-dependent response learning task. Results indicated that, relative to non-stressed control rats, SPS rats displayed slower acquisition in the place learning task and faster acquisition in the response learning task. In addition, extinction of place learning and response learning was impaired in rats exposed to SPS, relative to non-stressed controls. The influence of SPS on hippocampal spatial memory and DLS habit memory observed in the present study may be relevant to understanding some common features of PTSD, including hippocampal memory deficits, habit-like avoidance responses to trauma-related stimuli, and greater likelihood of developing drug addiction and alcoholism.
机译：高水平的情绪唤醒会损害海马介导的空间记忆，并增强由背外侧纹状体（DLS）介导的刺激反应（S-R）习惯记忆。进行本研究以确定在创伤后应激障碍（PTSD）的动物模型中这些记忆系统是否可能受到类似的影响。对Sprague-Dawley大鼠进行“单次持续应激”（SPS）程序，一周后接受正迷宫的两种不同版本之一的训练：海马依赖位置学习任务或DLS依赖反应学习任务。结果表明，相对于非应激对照组，SPS大鼠在场所学习任务中表现出较慢的获取，而在响应学习任务中表现出较快的获取。此外，相对于无压力的对照组，暴露于SPS的大鼠的位置学习和反应学习的消失受到损害。在本研究中观察到的SPS对海马空间记忆和DLS习惯记忆的影响可能与理解PTSD的一些共同特征有关，包括海马记忆缺陷，对创伤相关刺激的习惯样回避反应以及开发药物的更大可能性成瘾和酗酒。

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