• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Pediatrics >Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction
【24h】

Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction

机译：小儿脓毒症的液体大块疗法：当前的知识和未来的方向

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sepsis is a leading cause of morbidity and mortality in children with a worldwide prevalence in pediatric intensive care units of approximately 8%. Fluid bolus therapy (FBT) is a first line therapy for resuscitation of septic shock and has been a recommendation of international guidelines for nearly two decades. The evidence base supporting these guidelines are based on limited data including animal studies and case control studies. In recent times, evidence suggesting harm from fluid in terms of morbidity and mortality have generated interest in evaluating FBT. In view of this, studies of fluid restrictive strategies in adults and children have emerged. The complexity of studying FBT relates to several points. Firstly, the physiological and haemodynamic response to FBT including magnitude and duration is not well described in children. Secondly, assessment of the circulation is based on non-specific clinical signs and limited haemodynamic monitoring with limited physiological targets. Thirdly, FBT exists in a complex myriad of pathophysiological responses to sepsis and other confounding therapies. Despite this, a greater understanding of the role of FBT in terms of the physiological response and possible harm is warranted. This review outlines current knowledge and future direction for FBT in sepsis.
机译：败血症是儿童发病和死亡的主要原因，儿科重症监护病房的全球患病率约为8％。液体推注疗法（FBT）是复苏感染性休克的一线疗法，近二十年来一直是国际指南的建议。支持这些指南的证据基础是基于有限的数据，包括动物研究和病例对照研究。近年来，证据表明液体对发病率和死亡率的危害已引起人们对FBT评估的兴趣。鉴于此，已经出现了对成人和儿童的液体限制策略的研究。研究FBT的复杂性涉及几个方面。首先，儿童对FBT的生理和血液动力学反应（包括强度和持续时间）的描述不充分。其次，对血液循环的评估是基于非特定的临床体征和以有限的生理指标进行的有限的血液动力学监测。第三，FBT存在于对败血症和其他混杂疗法的多种病理生理反应中。尽管如此，仍需进一步了解FBT在生理反应和可能的危害方面的作用。这篇综述概述了败血症中FBT的当前知识和未来方向。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号