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首页> 外文期刊>Medical Hypothesis, Discovery & Innovation Ophthalmology Journal >Outcomes of Trabeculectomy With and Without Mitomycin C in Pseudoexfoliative Glaucoma Compared With Mitomycin C in Primary Open Angle Glaucoma
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Outcomes of Trabeculectomy With and Without Mitomycin C in Pseudoexfoliative Glaucoma Compared With Mitomycin C in Primary Open Angle Glaucoma

机译：假性剥脱性青光眼小梁切除术合并或不合并丝裂霉素C的结果与原发性开角型青光眼丝裂霉素C的比较

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The aim of this study was to evaluate the outcomes of trabeculectomy with mitomycin C (MMC) in patients with Pseudoexfoliative Glaucoma (PXG) and compare the results with the outcomes of trabeculectomy without MMC in PXG and with MMC in Primary Open Angle Glaucoma (POAG). Ninety eyes (76 patients) submitted to trabeculectomy were included in a one-year retrospective study. Fifty-eight eyes with PXG were divided into group 1 (28 eyes) and group 2 (30 eyes), with and without MMC application respectively. Then, the group 1 results were compared with 32 eyes with POAG that performed trabeculectomy with MMC (group 3). Main outcome measures were intraocular pressure (IOP), number of IOP lowering medications, rate of bleb failure (encapsulation, flattening and/or vascularization) and the number of eyes submitted to surgical procedures after trabeculectomy (needling, 5-fluorouracil – 5FU or 2nd trabeculectomy). Results revealed that compared to trabeculectomy with MMC in POAG and trabeculectomy with MMC in PXG, trabeculectomy without MMC in PXG leads to higher IOP (preoperative mean ± standard deviation [SD] was 28.6 ± 5.4 mmHg in group 1, 32.2 ± 8.2 mmHg in group 2 and 26.1 ± 6.5 mmHg in group 3; and after one year was 13.9 ± 3.9 mmHg in group 1, 16.1 ± 5.9 mmHg in group 2 and 12.5 ± 4.0 mmHg in group 3); higher number of IOP lowering medications (preoperative mean was 3.1 ± 0.60 in group 1, 2.8 ± 0.81 in group 2 and 3.4 ± 0.76 in group 3; and after one year was 1.1 ± 1.1 in group 1, 1.1 ± 1.0 in group 2 and 0.33 ± 0.89 in group 3); higher prevalence of bleb failure (47% in group 1, 53% in group 2, and 18% in group 3); and increased participation in surgical procedures following trabeculectomy (47% in group 1, 57% in group 2, and 6% in group 3). We concluded that trabeculectomy without MMC in PXG had the worst surgical outcome. Thus, PXG appears to be a potential risk factor for filtration bleb failure. Therefore, it could be considered in surgical protocols of MMC application.
机译：这项研究的目的是评估假性剥脱性青光眼（PXG）患者行丝裂霉素C（MMC）小梁切除术的结果，并将其与不伴MMC的小梁切除术和PXG合并MMC的原发性开角型青光眼（POAG）的结果进行比较。 。一项为期一年的回顾性研究包括了接受小梁切除术的90眼（76例患者）。 58只有PXG的眼分别分为第1组（28只眼）和第2组（30只眼），分别使用和不使用MMC。然后，将第1组的结果与32眼经POAG行MMC小梁切除术的眼进行比较（第3组）。主要结局指标包括眼压（IOP），降低IOP的药物数量，起泡失败率（包囊，扁平和/或血管化）以及小梁切除术后接受手术的眼睛数量（针刺，5-氟尿嘧啶– 5FU或第二小梁切除术）。结果显示，与在POAG中使用MMC的小梁切除术和在PXG中使用MMC的小梁切除术相比，在PXG中不使用MMC的小梁切除术导致更高的IOP（第1组的术前平均±标准差[SD]为28.6±5.4 mmHg，第1组为32.2±8.2 mmHg第3组为2和26.1±6.5 mmHg;一年后，第1组为13.9±3.9 mmHg，第2组为16.1±5.9 mmHg，第3组为12.5±4.0 mmHg）;降低IOP的药物数量更高（第1组术前平均值为3.1±0.60，第2组为2.8±0.81，第3组为3.4±0.76;一年后，第1组为1.1±1.1，第2组为1.1±1.0第三组为0.33±0.89）;气泡衰竭的患病率更高（第1组为47％，第2组为53％，第3组为18％）;以及小梁切除术后对手术程序的参与增加（第1组为47％，第2组为57％，第3组为6％）。我们得出的结论是，PXG中无MMC的小梁切除术的手术效果最差。因此，PXG似乎是导致滤泡故障的潜在危险因素。因此，可以在MMC应用的外科手术方案中考虑。

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