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首页> 外文期刊>Medical Journal of Shree Birendra Hospital >Induction Characteristics of Propofol in Children: Comparision with Thiopentone
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Induction Characteristics of Propofol in Children: Comparision with Thiopentone

机译：儿童异丙酚的诱导特性：与硫喷妥钠比较

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Introduction: Induction of anaesthesia has been dominated by intravenous induction agents. The commonest inductionagent in use is Sodium Thiopentone. However it is increasingly being replaced by Propofol. The advantage of propofolis faster induction, rapid and clear headed recovery and less postoperative nausea and vomiting. Very little research has been done to compare propofol with thiopentone in children. The aim of this study was to compare the anesthetic effects of thiopentone and propofol in children.Methods: This prospective comparative study was conducted in 60 consecutive children undergoing elective surgery. The study compared induction characteristics between the two drugs. The aim and objectives was to compare the induction characteristics of 1% propofol with another popular intravenous anesthetic 2.5 % thiopentone.Results: The study showed that the drugs have similar induction characteristics but there was difference in terms of heart rate, hypotension, apnoea and pain on injection. The heart rate ranged from 103.9 to 107.2 beats per minute in propofol group and for the thiopentone group the changes in heart rate was from 96 to 101 beats per minute. The mean systolic blood pressure in the propofol group was between 91.63 to 97.9 mm of Hg and for thiopentone was between 94.63 and 95.73 mm of Hg. The diastolic blood pressure ranged from 55.5 to 60.23 mm of Hg in the propofol group whereas for thiopentone it ranged between 60.26 to 62.76 mm of Hg. The basal Spo2 being 99.06 in the propofol group dipped to 98.56 in the propofol group and for the thiopentone group the value remained between 98.7 to 99.3%.Conclusions: Propofol can safely be used as a replacement to thiopentone for pediatric day care surgeries.Medical Journal of Shree Birendra Hospital; January-June 2013/vol.12/Issue1/4-7http://dx.doi.org/10.3126/mjsbh.v12i1.9082
机译：简介：麻醉的诱导一直以静脉内诱导剂为主。使用的最常见的诱导剂是硫代硫酸钠。然而，它越来越被丙泊酚取代。异丙酚的优点是诱导更快，头部恢复迅速清晰，术后恶心和呕吐更少。在儿童中比较异丙酚和硫喷妥酮的研究很少。这项研究的目的是比较硫喷妥酮和丙泊酚对儿童的麻醉作用。方法：这项前瞻性比较研究是对60例接受择期手术的儿童进行的。该研究比较了两种药物之间的诱导特性。目的和目的是比较1％异丙酚与另一种常用的2.5％硫喷妥钠静脉麻醉药的诱导特性。结果：研究表明，该药物具有相似的诱导特性，但在心率，低血压，呼吸暂停和疼痛方面存在差异注射时。异丙酚组的心率范围为每分钟103.9至107.2次搏动，而硫喷妥酮组的心率变化范围为每分钟96至101次搏动。丙泊酚组的平均收缩压在91.63至97.9毫米汞柱之间，而硫喷通的平均收缩压在94.63至95.73毫米汞柱之间。丙泊酚组的舒张压范围为55.5至60.23毫米汞柱，而硫代戊酮的舒张压范围为60.26至62.76毫米汞柱。丙泊酚组的基础Spo2为99.06，而丙泊酚组的基础Spo2降至98.56，而硫喷妥酮组的Spo2值仍在98.7％至99.3％之间。 Shree Birendra医院; 2013年1月至6月/vol.12/Issue1/4-7http://dx.doi.org/10.3126/mjsbh.v12i1.9082

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