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首页> 外文期刊>Medical and Health Science Journal >Effect of long term exposure of low doses of lambda- cyhalothrin on the level of lipid peroxidation and antioxidant enzymes of the pregnant rats and their offspring
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Effect of long term exposure of low doses of lambda- cyhalothrin on the level of lipid peroxidation and antioxidant enzymes of the pregnant rats and their offspring

机译：长期暴露于小剂量氟氯氰菊酯对孕鼠及其后代脂质过氧化和抗氧化酶水平的影响

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摘要

Lambda- cyhalothrin (LCT) is a pyrethroid insecticide class, which is widely used for pest control in agriculture, public health, home and garden. In the present study we investigated the effect of long term exposure of low doses of the LCT on the state of lipid peroxidation and antioxidant protection of pregnant rats and their offspring. It was revealed, that prolonged exposure of lambda-cyhalothrin leads to the development of oxidative stress in both of pregnant females and their offspring. The highest level of lipid peroxidation detected on 14-21 days of pregnancy, which was accompanied by a reduction in activity of antioxidant enzymes. In the offspring highest level of oxidative stress observed on 7-14 days of lactation. The degree of oxidative stress in offspring decreases as the cessation of receipt of a pesticide or its toxic metabolites in breast milk.
机译：氯氟氰菊酯（LCT）是一种拟除虫菊酯类杀虫剂，广泛用于农业，公共卫生，家庭和花园的害虫防治。在本研究中，我们调查了长期低剂量LCT暴露对妊娠大鼠及其后代脂质过氧化状态和抗氧化保护状态的影响。据透露，长时间暴露于氟氯氰菊酯会导致孕妇及其后代的氧化应激发展。在怀孕的14-21天检测到最高的脂质过氧化水平，同时伴随着抗氧化酶活性的降低。在哺乳期7-14天后代中最高水平的氧化应激。后代中的氧化应激程度随着母乳中停止使用农药或其有毒代谢产物而降低。

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