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首页> 外文期刊>Medical and Health Science Journal >Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats
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Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats

机译：抗坏血酸对成年Wistar大鼠乙酸铅致小脑损伤的预防活性

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Among the environmental contaminants, lead is one of the most hazardous to living matter. In mammals, the main target is the central nervous system, particularly in the young. Ascorbic acid is an antioxidant which is a substance that may protect your cells against the effects of free radicals. This study investigated Experiment the protective effect of ascorbic acid on the cerebellum of adult Wistar rats following oral administration of different doses of Lead acetate. Thirty adult Wistar rats of average weight of 215g were used in this study. The animals were divided into five (5) groups of six animals per group and were administered different doses of lead acetate (60mg/kg bwt of 1/10th LD50 and 30mg/kg bwt of 1/20th of LD50) and ascorbic acid (4.3mg/kg bwt) orally over a period of three (3) weeks.Group 1 (control) was administered distilled water and Group 2 and 3 were administered 30mg/kg and 60mg/kg of Lead acetate respectively while Group 4 and 5 were given co-administration of 30mg/kg of Lead acetate 4.3mg/kg of ascorbic acid and 60gm/kg of Lead acetate 4.3mg/kg of ascorbic acid respectively. Histopathologically, Lead acetate induced cellular damage in the cerebellum of adult Wistar rats and it was also observed that ascorbic acid prevents or minimize lead-induced cellular damage in the cerebellum of adult Wistar rats.
机译：在环境污染物中，铅是对生物危害最大的物质之一。在哺乳动物中，主要目标是中枢神经系统，尤其是在年轻人中。抗坏血酸是一种抗氧化剂，可以保护您的细胞免受自由基的侵害。这项研究调查了抗坏血酸对口服不同剂量乙酸铅后对成年Wistar大鼠小脑的保护作用。在该研究中使用了30只平均体重为215g的成年Wistar大鼠。将动物分为五（5）组，每组六只动物，分别给予不同剂量的醋酸铅（60mg / kg bwt的LD50的1/10和30mg / kg bwt的LD50的1/20）和抗坏血酸（4.3三（3）周内口服（mg / kg bwt）。第1组（对照组）给予蒸馏水，第2组和第3组分别给予30mg / kg和60mg / kg乙酸铅，而第4组和第5组给予分别并用30mg / kg乙酸铅4.3mg / kg抗坏血酸和60gm / kg乙酸铅4.3mg / kg抗坏血酸。在组织病理学上，乙酸铅诱导成年Wistar大鼠小脑的细胞损伤，并且还观察到抗坏血酸阻止或最小化了铅诱导的成年Wistar大鼠小脑的细胞损伤。

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