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首页> 外文期刊>Frontiers in Human Neuroscience >Impaired Activation of Visual Attention Network for Motion Salience Is Accompanied by Reduced Functional Connectivity between Frontal Eye Fields and Visual Cortex in Strabismic Amblyopia
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Impaired Activation of Visual Attention Network for Motion Salience Is Accompanied by Reduced Functional Connectivity between Frontal Eye Fields and Visual Cortex in Strabismic Amblyopia

机译：斜视性弱视的额叶视野和视觉皮层之间的功能连接性降低，伴随着视觉注意力网络对运动显着性的激活受损。

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Strabismic amblyopia is now acknowledged to be more than a simple loss of acuity and to involve alterations in visually driven attention, though whether this applies to both stimulus-driven and goal-directed attention has not been explored. Hence we investigated monocular threshold performance during a motion salience-driven attention task involving detection of a coherent dot motion target in one of four quadrants in adult controls and those with strabismic amblyopia. Psychophysical motion thresholds were impaired for the strabismic amblyopic eye, requiring longer inspection time and consequently slower target speed for detection compared to the fellow eye or control eyes. We compared fMRI activation and functional connectivity between four ROIs of the occipital-parieto-frontal visual attention network [primary visual cortex (V1), motion sensitive area V5, intraparietal sulcus (IPS) and frontal eye fields (FEF)], during a suprathreshold version of the motion-driven attention task, and also a simple goal-directed task, requiring voluntary saccades to targets randomly appearing along a horizontal line. Activation was compared when viewed monocularly by controls and the amblyopic and its fellow eye in strabismics. BOLD activation was weaker in IPS, FEF and V5 for both tasks when viewing through the amblyopic eye compared to viewing through the fellow eye or control participants' non-dominant eye. No difference in V1 activation was seen between the amblyopic and fellow eye, nor between the two eyes of control participants during the motion salience task, though V1 activation was significantly less through the amblyopic eye than through the fellow eye and control group non-dominant eye viewing during the voluntary saccade task. Functional correlations of ROIs within the attention network were impaired through the amblyopic eye during the motion salience task, whereas this was not the case during the voluntary saccade task. Specifically, FEF showed reduced functional connectivity with visual cortical nodes during the motion salience task through the amblyopic eye, despite suprathreshold detection performance. This suggests that the reduced ability of the amblyopic eye to activate the frontal components of the attention networks may help explain the aberrant control of visual attention and eye movements in amblyopes.
机译：斜视性弱视现在被认为不仅仅是视力的简单丧失，而且还涉及视觉驱动注意力的改变，尽管尚未探讨这是否适用于刺激驱动注意力和目标导向注意力。因此，我们在运动显着性驱动的注意力任务中调查了单眼阈值性能，该任务涉及在成人控件和患有斜视性弱视的四个象限之一中检测到连贯的点运动目标。斜视性弱视眼睛的心理运动阈值受损，与另一只眼睛或对照眼睛相比，需要更长的检查时间，因此检测目标速度较慢。我们比较了阈上阈值期间枕-顶-额叶视觉注意网络[主要视觉皮层（V1），运动敏感区V5，顶壁沟（IPS）和额叶视野（FEF）]的四个ROI之间的fMRI激活和功能连接性是运动驱动注意力任务的一种形式，也是一种简单的目标导向任务，需要自愿扫视到随机出现在水平线上的目标。当对照和弱视患者及其斜视的单眼观察时，比较了激活情况。与通过同眼或对照参与者的非优势眼观看相比，通过弱视眼进行观看时，两项任务的IPS，FEF和V5的BOLD激活均较弱。在运动显着任务期间，弱视和另一只眼睛之间以及对照组参与者的两只眼睛之间均未观察到V1激活的差异，尽管通过弱视眼的V1激活明显少于通过另一只眼睛和对照组的非优势眼在自愿的扫视任务中观看。在运动显着任务期间，通过弱视弱视了注意力网络内ROI的功能相关性，而在自愿进行扫视任务时，情况并非如此。具体而言，尽管具有超阈值检测性能，但在通过弱视进行运动显着性任务期间，FEF显示出与视觉皮层结点的功能连接性降低。这表明弱视眼睛激活注意力网络的额叶成分的能力降低，可能有助于解释弱视对视觉注意力和眼睛运动的异常控制。

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