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首页> 外文期刊>Medical Devices: Evidence and Research >Assessment of the added value of the Twente Photoacoustic Mammoscope in breast cancer diagnosis
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Assessment of the added value of the Twente Photoacoustic Mammoscope in breast cancer diagnosis

机译：Twente光声乳房镜在乳腺癌诊断中的附加价值评估

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Purpose: Photoacoustic (PA) imaging is a recently developed breast cancer imaging technique. In order to enhance successful clinical implementation, we quantified the potential clinical value of different scenarios incorporating PA imaging by means of multi-criteria analysis. From this analysis, the most promising area of application for PA imaging in breast cancer diagnosis is determined, and recommendations are provided to optimize the design of PA imaging.Methods: The added value of PA imaging was assessed in two areas of application in the diagnostic track. These areas include PA imaging as an alternative to x-ray mammography and ultrasonography in early stage diagnosis, and PA imaging as an alternative to Magnetic Resonance Imaging (MRI) in later stage diagnosis. The added value of PA imaging was assessed with respect to four main criteria (costs, diagnostic performance, patient comfort and risks). An expert panel composed of medical, technical and management experts was asked to assess the relative importance of the criteria in comparing the alternative diagnostic devices. The judgments of the experts were quantified based on the validated pairwise comparison technique of the Analytic Hierarchy Process, a technique for multi-criteria analysis. Sensitivity analysis was applied to account for the uncertainty of the outcomes.Results: Among the considered alternatives, PA imaging is the preferred technique due to its non-invasiveness, low cost and low risks. However, the experts do not expect large differences in diagnostic performance. The outcomes suggest that design changes to improve the diagnostic performance of PA imaging should focus on the quality of the reconstruction algorithm, detector sensitivity, detector bandwidth and the number of wavelengths used.Conclusion: The AHP method was useful in recommending the most promising area of application in the diagnostic track for which PA imaging can be implemented, this being early diagnosis, as a substitute for the combined use of x-ray mammography and ultrasonography.
机译：目的：光声（PA）成像是一种最新开发的乳腺癌成像技术。为了增强成功的临床实施，我们通过多标准分析定量了结合PA成像的不同方案的潜在临床价值。通过该分析，确定了PA成像在乳腺癌诊断中最有前景的应用领域，并提供了一些建议以优化PA成像的设计。方法：评估了PA成像在诊断中的两个应用领域的附加值跟踪。这些领域包括：在早期诊断中，PA成像可替代X线乳房X线摄影和超声检查;在后期诊断中，PA成像可替代磁共振成像（MRI）。根据四个主要标准（成本，诊断性能，患者舒适度和风险）评估了PA成像的附加值。由医学，技术和管理专家组成的专家小组被要求评估标准在比较其他诊断设备时的相对重要性。专家的判断是基于经过验证的成对比较技术“层次分析法”（一种用于多标准分析的技术）进行量化的。结果：在考虑的替代方案中，PA成像由于其无创性，低成本和低风险而成为首选技术。但是，专家们并不期望诊断性能有很大差异。结果表明，为改善PA成像的诊断性能而进行的设计更改应着重于重建算法的质量，检测器灵敏度，检测器带宽和所用波长的数量。结论：AHP方法可用于推荐最有希望的应用领域。可以在可以实施PA成像的诊断路径中进行应用，这是早期诊断，可以替代X线乳房X线照片和超声检查的结合使用。

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