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Significance of hormonal receptors in benign breast diseases

机译：激素受体在乳腺良性疾病中的意义

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Background: The association between hormonal receptor expression and cell proliferation in breast tissues remains controversial. The aim of this study was to evaluate hormonal receptor concentrations in various types of benign breast lesions.Material/Methods: We evaluated the quantitative estrogen (ER) and progesterone receptor (PR) content of breast epithelium in different benign lesions of 126 women who underwent breast biopsy (benign results). Benign breast lesions were divided according to proliferation activity criteria into: nonproliferative lesions, proliferative lesions without atypia, atypical hyperplasia and the most common entity - fibroadenomas. Evaluation of hormonal receptors was performed by means of Amersham's cytosolic saturation analysis with a 3H radioligand.Results: We documented the significant difference of hormonal receptor concentrations dependent of the proliferative activity of breast lesions. Our data demonstrated the association of atypical breast hyperplasia with high ER and PR contents, with a prevalence of ER.Conclusions: This event should be evaluated as a marker of increased breast cancer risk. Careful follow-up and treatment of these patients is a necessity. Based on hormonal receptor concentrations, a proper hormonal therapy may be selected in order to inhibit the proliferative potential of the breast lesion.
机译：背景：激素受体表达与乳腺组织中细胞增殖之间的关联仍存在争议。这项研究的目的是评估各种类型的乳腺良性病变中的激素受体浓度。材料/方法：我们评估了126例行不同良性病变的女性乳房上皮的定量雌激素（ER）和孕激素受体（PR）含量。乳房活检（良性结果）。根据增殖活性标准将良性乳腺病变分为：非增生性病变，无非典型性增生性病变，非典型增生和最常见的实体-纤维腺瘤。荷尔蒙受体的评估通过Amersham的3H放射性配体胞质饱和度分析进行。我们的数据表明非典型性乳腺增生与高ER和PR含量与ER患病率相关。结论：该事件应作为增加乳腺癌风险的标志物进行评估。对这些患者进行认真的随访和治疗是必要的。基于激素受体浓度，可以选择适当的激素疗法以抑制乳腺病变的增生潜力。

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