首页> 外国专利> Mesoprogenists (progesterone receptor modulators) are benign hormones? For the treatment and prevention of invasive ecological diseases

Mesoprogenists (progesterone receptor modulators) are benign hormones? For the treatment and prevention of invasive ecological diseases

机译：中生代（孕激素受体调节剂）是良性激素吗？用于治疗和预防侵入性生态疾病

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摘要

This present invention disclosed the use of mesoprogestins, a new class of progesterone receptor modulators (PRMs), for the treatment and prevention of benign hormone dependent gynecological disorders: a) for the treatment of gynecological disorder such as endometriosis, uterine fibroids, postoperative peritoneal adhesions, dysfunctional bleeding (metrorrhagia, menorrhagia) and dysmenorrhea; b) for the prevention of gynecological disorders such as postoperative, peritoneal adhesions, dysfunctional uterine bleeding (metrorrhagia, menorrhagia) and dysmenorrhea; and c) a method of treatment and prevention of the above mentioned disorders in a female, preferably in a human female, in need of treatment or prevention of one or more of these disorders, with an effective amount of a mesoprogestin. Mesoprogestins are defined as compounds possessing both agonistic and antagonistic activities at the progesterone receptor (PR) in vivo. They stabilize the function of PR at an intermediate level of agonistic and antagonistic. Corresponding functional states cannot be achieved with progestins or antiprogestins. The daily dose of mesoprogestin is 0.5 to 100 mg, preferably 5.0 to 50 mg and most preferably 10 to 25 mg. J867, J912, J956 and J1042 are the mesoprogestins preferred according to the invention.

机译：本发明公开了新型孕酮受体调节剂中孕激素在治疗和预防良性激素依赖性妇科疾病中的用途：a）治疗妇科疾病，例如子宫内膜异位，子宫肌瘤，术后腹膜粘连，功能失调性出血（月经过多，月经过多）和痛经; b）预防妇科疾病，如术后，腹膜粘连，子宫功能失调（子宫出血，月经过多）和痛经; c）一种治疗和预防上述疾病的方法，该方法在女性中，优选在人类女性中，需要用有效量的中孕激素治疗或预防这些疾病中的一种或多种。中孕激素定义为在体内对孕激素受体（PR）具有激动和拮抗活性的化合物。它们将PR的功能稳定在激动和拮抗的中间水平。孕激素或抗孕激素不能达到相应的功能状态。中孕激素的日剂量为0.5至100mg，优选为5.0至50mg，最优选为10至25mg。 J867，J912，J956和J1042是根据本发明优选的中孕激素。

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公开/公告号EE05172B1

专利类型
公开/公告日2009-06-15

原文格式PDF
申请/专利权人 JENAPHARM GMBH & CO. KG;
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申请/专利号EEP200200104
发明设计人 KRISTOF CHWALISZ;WALTER ELGER;GERD SCHUBERT;
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申请日2000-08-31
分类号A61K31/4365;A61K45;A61K31/567;A61K31/57;A61K38;A61K38/08;A61K38/09;A61K38/14;A61K45/06;A61P15;A61P15/04;A61P35;
国家 EE
入库时间 2022-08-21 19:27:58

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