Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases

Nian Liu; Bin Zhou; Guangxun Zhu

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Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases

机译：带有Kazal基序的还原诱导半胱氨酸富集蛋白（RECK）在调节牙周疾病中基质金属蛋白酶（MMPs）表达中的潜在作用

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ABSTRACT Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined.RECK (reversion-inducing cysteine-rich protein with Kazal motifs), a novel membrane-anchored inhibitor of MMPs, could regulate the expressions of MMP-2, 9 and MT1-MMP as a cell surface-signaling molecule. Thus, we propose that RECK may play an important role in regulating MMPs in the ECM degradation of periodontal diseases. The RECK/MMPs signaling pathway could provide a new approach for prevention and treatment of RECK in periodontal diseases by blocking MMPs.

机译：摘要牙周疾病的特征在于牙周组织细胞外基质（ECM）的病理破坏。基质金属蛋白酶（MMP）是ECM降解的重要组成部分。然而，尚未确定牙周疾病中MMPs表达水平的调控。一种新型的膜锚定MMPs抑制剂RECK（具有Kazal主题的回复诱导型富含半胱氨酸的蛋白）可以调节MMP-2、9和MMPs的表达。 MT1-MMP作为细胞表面信号分子。因此，我们建议RECK可能在调节牙周疾病的ECM降解中的MMP中起重要作用。 RECK / MMPs信号通路可以通过阻断MMPs为牙周疾病的RECK防治提供新的途径。

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《Medical science monitor :》 |2016年第2期|共3页
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Nian Liu; Bin Zhou; Guangxun Zhu;
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1. Expression of matrix metalloproteinases-2,-9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease [J] . Liu Nian, Cao Yingguang, Zhu Guangxun Archives of Oral Biology . 2017,第期

机译：基质金属蛋白酶-2，-9和逆转诱导的富含半胱氨酸富含半胱氨酸的富含脑膜母蛋白在牙周健康和疾病中
2. Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis fr [J] . Oshima T, Kunisaki C, Yoshihara K, Oncology reports . 2008,第5期

机译：大肠癌患者基质金属蛋白酶基因表达及具有Kazal基序的回复诱导富半胱氨酸蛋白表达的临床病理意义：MMP-2基因表达可作为肝转移的有用预测指标
3. MicroRNA-15a promotes neuroblastoma migration by targeting reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and regulating matrix metalloproteinase-9 expression [J] . Chen Xin, Bao Buhe, Lu Hongting, The FEBS journal . 2013,第3期

机译：MicroRNA-15a通过靶向具有Kazal基序（RECK）的诱导还原的富含半胱氨酸的蛋白并调节基质金属蛋白酶9表达来促进神经母细胞瘤迁移
4. THE ROLE OF MATRIX METALLOPROTEINASES (MMPs) AND TISSUE INHIBITORS OF METALLOPROTEINASES (TIMPs) IN MESANGIAL MATRIX REPLACEMENT IN AL-AMYLOiDOSIS: AN 1N-VIVO AND IN-VITRO CORRELATIVE STUDY [C] . J. Keeling, S. Dempse, L. Joseph, International Symposium on Amyloidosis . 2005

机译：基质金属蛋白酶（MMP）和组织抑制剂的作用（MMP）和组织抑制剂在亚氨基化症中的Mesangial基质中的替代性：1N-体内和体外相关研究
5. Regulation of membrane type-matrix metalloproteinases (MT-MMPs) in non-malignant and malignant cells. [D] . Kim, Seaho. 2009

机译：非恶性和恶性细胞中膜型基质金属蛋白酶（MT-MMPs）的调节。
6. Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases [O] . Nian Liu, Bin Zhou, Guangxun Zhu 2016

机译：Kazal母题（RECK）诱导富半胱氨酸还原蛋白在牙周疾病基质金属蛋白酶（MMPs）表达调控中的潜在作用
7. Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases [O] . Nian Liu, Bin Zhou, Guangxun Zhu 2016

机译：富含kazal主题（RECK）在牙周病中的基质金属蛋白酶（MMPs）表达调节中，富含富含半胱氨酸富含蛋白质（RECK）的潜在作用
8. Extracellular Matrix Regulations of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts. [R] . Hernandez-Barrantes, S., Fridman, R. 2002

机译：人乳腺成纤维细胞膜型1基质金属蛋白酶（mT1-mmp）和基质金属蛋白酶-2（mmp-2）的细胞外基质调节。

Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases

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