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Effectiveness of interferon alpha treatment in children of different ages with chronic hepatitis B

机译：干扰素α治疗不同年龄的慢性乙型肝炎儿童的有效性

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The aim of the work was the evaluation of the interferon alpha (IFN) treatment in children of different ages with chronic hepatitis B. Observation was carried out on a group of 63 children with clinically and histopathologically diagnosed chronic hepatitis. 39 children out of this group (24 up to s years of age and 15 over 3 years old) with HBs and HBe antigenemia lasting for over 6 months were qualified for IFN treatment. The control group consisted of 24 children with cph without treatment. 12 months after IFN treatment termination in the subgroup of younger children regression of HBV DNA polymerase activity was observed in 54.4% of cases; 63.6% of children seroconverted to antiHBe, and 12.5% seroconverted to antiHBs as well. In the subgroup of older children regression of HBV DNA polymerase activity was observed in 50.0% of children and the same percentage seroconverted to antiHBe. In the control group 25.0% of untreated children seroconverted to antiHBe.
机译：这项工作的目的是评估不同年龄的慢性乙型肝炎儿童的干扰素α（IFN）治疗。对63名经临床和组织病理学诊断为慢性肝炎的儿童进行了观察。该组中的39名儿童（24岁至s岁，15名3岁以上）持续超过6个月的HBs和HBe抗原血症符合IFN治疗的条件。对照组由24名未经治疗的cph患儿组成。在年龄较小的儿童亚组中，IFN治疗终止后12个月，观察到54.4％的患者HBV DNA聚合酶活性下降。 63.6％的儿童血清转化为抗HBe，12.5％的血清转化为抗HBs。在较大的儿童亚组中，在50.0％的儿童中观察到HBV DNA聚合酶活性下降，并且相同比例的血清转化为抗HBe。对照组中有25.0％的未治疗儿童血清转化为抗HBe。

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