...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical science monitor : >Long-term monitoring of an immune response to tumour and LDH viral antigen in patients with brest cancer
【24h】

Long-term monitoring of an immune response to tumour and LDH viral antigen in patients with brest cancer

机译：长期监测乳腺癌患者对肿瘤和LDH病毒抗原的免疫反应

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We studied cell-mediated immunity (CMI) by means of an antigen prepared from the serum of C3H-H2K strain inbred mice infected by the LDH virus in 184 patients with breast carcinoma. The immune response to the LDH virus and breast cancer antigen was determined by the leukocyte adherence inhibition test (LAI test) and the analysis was carried out by means of the index of positivity (IP) and was significantly higher in patients with breast cancer (IP = 2.2±0.09) when compared with healthy blood donors (IP =0.9±0.05). Importantly, with regard to the time course of the immune response, we found a slight loss of antibodies over 12 to 18 months. To obtain a statistically significant reduction of the titre of antibodies, patients must be examined on a long-term basis (3-5 years). During the incubation of CD4Ly cells with both antigens, the creation of clusters of these lymphocytes was observed, often immediately after an addition of the antigen,whereas only two percent of the healthy donor blood induced this clustering.
机译：我们研究了一种抗原，该抗原是从184例乳腺癌患者中由LDH病毒感染的C3H-H2K菌株近交小鼠血清制备的抗原制备的。通过白细胞粘附抑制试验（LAI试验）确定了对LDH病毒和乳腺癌抗原的免疫反应，并通过阳性指数（IP）进行了分析，乳腺癌患者中的阳性率明显更高（IP与健康献血者相比（IP = 0.9±0.05）= 2.2±0.09）。重要的是，关于免疫反应的时间过程，我们发现在12到18个月内抗体略有丢失。为了获得统计学上显着降低的抗体滴度，必须对患者进行长期检查（3-5年）。在用两种抗原孵育CD4Ly细胞的过程中，通常在添加抗原后立即观察到了这些淋巴细胞簇的形成，而只有2％的健康供体血液诱导了这种簇。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号