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Antioxidant status of patients with well controlled type I diabetes

机译:良好控制的I型糖尿病患者的抗氧化状态

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17 non-diabetic subjects and 11 patiens with type I diabets - matched in age and BMI -were studied in order to evaluate the effects of well controlled diabets on antioxidant status. Mean duration of diabets was 10 years; a mean HbA1c value of 6 .06 -0.48% implied a good blood glucose control. All the diabetics subjects were on intensive insulin therapy and had no renal complications. Atherogen index (total cholesterol/HDL cholesterol) was practically identical in the two groups (3.05 vs 156 μM), but the difference was not significant (p=0.11). Antioxidant enzyme activities (erythrocyte superoxide dismutase and catalase, whole blood glutahione peroxidase) did not differ in the two groups. Similarly Total Antioxidant Status - a measure of overall antioxidant defense in plasma - and TBARS concentrations were not statistically different in controls and diabetics.We assume that type I diabets, when blood glucose is stictly controlled by intensive insulin therapy, is not accompanied by changes in the prooxidant - antioxidant balance.
机译:研究了17名非糖尿病受试者和11名年龄与BMI匹配的I型糖尿病患者,以评估控制良好的糖尿病对抗氧化剂状态的影响。糖尿病平均病程为10年; HbA1c的平均值为6 .06 -0.48%意味着血糖控制良好。所有的糖尿病患者都接受了强化胰岛素治疗,没有肾脏并发症。两组的动脉粥样硬化指数(总胆固醇/高密度脂蛋白胆固醇)实际上是相同的(3.05 vs 156μM),但差异不显着(p = 0.11)。两组的抗氧化酶活性(红细胞超氧化物歧化酶和过氧化氢酶,全血谷胱甘肽过氧化物酶)没有差异。同样,总抗氧化剂状态-衡量血浆中总体抗氧化剂防御能力的指标-以及对照组和糖尿病患者中TBARS的浓度在统计学上没有差异。我们假设I型糖尿病在严格的胰岛素治疗严格控制血糖的情况下并没有伴随血糖水平的变化。促氧化剂-抗氧化剂平衡。

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