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首页> 外文期刊>Medical science monitor : >Autologous gamete cryopreservation before hemopoietic stem cell transplantation
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Autologous gamete cryopreservation before hemopoietic stem cell transplantation

机译：造血干细胞移植前的自体配子冷冻保存

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Background: Infertility after hemopoietic stem cell transplantation (HST) is a serious problem for young patients. Autologous gamete collection before HST may be a promising strategy to overcome infertility.Material/Methods: From October 1988 to December 2003, six male and nine female patients with hematological malignancies had autologous gametes collected before HST. The data on autologous gamete collection were analyzed.Results: Sperm could be collected from three patients. However, in two of the three, the numbers and motility of the sperm were severely depleted because they received chemotherapy for one and 11 cycles,respectively. Normal sperm was only collected from one patient with myelodysplastic syndrome who had no history of receiving chemotherapy. One or more oocytes could be collected in fi ve ofnine female patients, although the fi ve received multiple cycles of chemotherapy. The successful oocyte collection was associated with an ovulation stimulant.Conclusions: Autologous oocye collection before HST may be possible, even if patients receive multiple cycles of chemotherapy. In contrast, autologous sperm collection before HST may be diffi cult after patientsreceive chemotherapy. Successful pregnancy using autologous gametes after HST remains extremely diffi cult, especially in female patients; however, it is important to give information on infertility and autologous gamete collection to patients scheduled for HST.
机译：背景：造血干细胞移植（HST）后的不孕症是年轻患者的严重问题。材料/方法：从1988年10月至2003年12月，有6例男性和9例血液系统恶性肿瘤患者在进行HST之前收集了自体配子，这可能是克服不育症的一种有前途的策略。结果：3例患者的精子可被收集。然而，在三分之二的精子中，精子的数量和活力严重耗尽，因为它们分别接受了一个和11个周期的化疗。仅从一名没有接受过化疗史的骨髓增生异常综合症患者中收集了正常的精子。尽管五个女性接受了多个化疗周期，但仍可以在五个女性患者中收集一个或多个卵母细胞。结论：成功进行卵母细胞收集可能与促排卵有关。结论：即使患者接受了多个化疗周期，也可能在HST之前自体收集卵。相反，在接受化疗后，很难在HST之前收集自体精子。 HST后使用自体配子成功怀孕仍然非常困难，特别是在女性患者中;但是，重要的是要向计划进行HST的患者提供有关不育和自体配子收集的信息。

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