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Thyroid volume and hormone response in the early kidney transplants

机译：早期肾脏移植中的甲状腺体积和激素反应

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Background:Thyroid hormones could affect renal function, and conversely renal function disturbances may affect thyroid function. Disturbances of the thyroid hormone concentration are often connected with thyroid gland enlargement. The aim of study was to estimate the function and morphology of the thyroid and kidney graft after kidney transplantation. As the indicator of thyroid and renal function we have used thyroid gland volume, plasma concentration of T3, reverse rT3, creatinine concentration, and renal arteries RI.Material/Methods: Studied group included 17 individuals after kidney transplantation, with stabile graft function. The control group included 18 individuals after various surgical procedures. The estimated parameters were: thyroid volume, renal arteries resistive index, concentrations of creatinine,T3 and rT3.The parameters were controlled before transplantation (surgery), the day after, and at 3 rd, 6 th and 10 th day after surgery.Results: All patients, before and after surgical procedure, were clinically euthyroid. Mean creatinine concentration showed tendency to diminish. Statistical analysis revealed positive correlation between concentration of creatinine and volume of thyroid (R Spearman=0.46, p=0.05). Till the 6 th day after transplantation T3 concentration diminished, and at the 10 th day presented tendency to rise. We found negative correlation between T3 concentration and renal arteries RI. The rT3 concentration during 10 days after transplantation was above the reference level.Conclusions: The FT3 level and thyroid volume correlates with kidney transplant function. The supplementary thyroid hormones administration should be considered before and after renal transplantation.
机译：背景：甲状腺激素可能会影响肾功能，反之，肾功能紊乱可能会影响甲状腺功能。甲状腺激素浓度紊乱通常与甲状腺增大有关。该研究的目的是评估肾脏移植后甲状腺和肾脏移植物的功能和形态。作为甲状腺和肾功能的指标，我们使用了甲状腺体积，血浆T3浓度，rT3反向，肌酐浓度和肾动脉RI。材料/方法：研究组包括17例肾移植后具有稳定移植功能的患者。对照组包括经过各种手术程序的18个人。估计参数为：甲状腺体积，肾动脉阻力指数，肌酐，T3和rT3的浓度，参数在移植前（手术），术后第二天以及术后第三，第六和第十天进行控制。 ：所有患者，在手术前后，临床上甲状腺功能正常。肌酐平均浓度呈下降趋势。统计分析显示肌酐浓度与甲状腺体积呈正相关（R Spearman = 0.46，p = 0.05）。到移植后第6天，T3浓度降低，并在第10天呈上升趋势。我们发现T3浓度与肾动脉RI之间呈负相关。移植后10天的rT3浓度高于参考水平。结论：FT3水平和甲状腺体积与肾移植功能有关。肾移植前后应考虑补充甲状腺激素。

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