首页> 外国专利> Processes for modulating the activity of a thyroid hormone receptor, for identification of a compound capable of deselectively modulating the activity of a thyroid hormone receptor isoform, for identification of a thyroid hormone receptor antagonist or antagonist ligand, and identification of a compound that selectively modulates the activity of a thyroid hormone receptor, peptide molecule, peptidomimetic or synthetic, and means of machine-readable data storage

Processes for modulating the activity of a thyroid hormone receptor, for identification of a compound capable of deselectively modulating the activity of a thyroid hormone receptor isoform, for identification of a thyroid hormone receptor antagonist or antagonist ligand, and identification of a compound that selectively modulates the activity of a thyroid hormone receptor, peptide molecule, peptidomimetic or synthetic, and means of machine-readable data storage

机译：调节甲状腺激素受体活性的方法，用于鉴定能够选择性地调节甲状腺激素受体同工型活性的化合物，用于鉴定甲状腺激素受体拮抗剂或拮抗剂配体，以及鉴定能选择性调节甲状腺激素受体拮抗剂的化合物的方法。甲状腺激素受体，肽分子，拟肽或合成的活性以及机器可读数据存储的方式

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"PROCESSES OF MODULATING THE ACTIVITY OF A THYROID HORMONE HUMAN RESTOR, PARIDENTIFYING A COMPOSITE CAPABELY DESELECTIVELY MODULATING THE ACTIVITY OF A THYROID HORMONE RECEPTOR, IDENTIFYING AN ANTHONYTIC LAYER QUESELETIVELY COMPOUND MODULATES THE ACTIVITY OF A THYROID HORMONE RECEPTOR, PEPTIDIC MOLECULE, PEPTIDOMIMETIC OR SYNTHETIC AND, MEANS OF STORAGE OF LEGIBLE DATA BY MACHINE ". The present invention provides new processes, particularly computational processes and compositions for the generation of synthetic nuclear receptor deligrants based on the three-dimensional structure of nuclear receptors, particularly the thyroid receptor (referred to herein as "TR"). Crystals, synthetic nuclear receptor ligands, and related processes are also provided.

机译：“调节甲状腺激素人类恢复素的活性，鉴别复合巨噬细胞的活性的过程，选择性地调节甲状腺激素受体的活化，鉴定胶体中的丙酮酸，胶体中的胶体呈胶体状通过机器存储合法数据的方式。本发明提供了基于核受体，特别是甲状腺受体（在本文中称为“ TR”）的三维结构产生合成核受体配体的新方法，特别是计算方法和组合物。还提供了晶体，合成核受体配体和相关方法。

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公开/公告号BR9815061A

专利类型
公开/公告日2001-11-20

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;
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申请/专利号BR19989815061
发明设计人 THOMAS S. SCANLAN;JOHN D. BAXTER;ROBERT J. FLETTERICK;RICHARD L. WAGNER;PETER J. KUSHNER;JAMES W. APRILETTI;BRIAN L. WESTFIELD;ANDREW K. SHIAU;
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申请日1998-11-25
分类号C07K14/00;
国家 BR
入库时间 2022-08-22 00:46:00

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