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首页> 外文期刊>Medical science monitor : >Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm
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Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm

机译：主动脉瘤患者血浆中不同亚细胞定位酶的活性

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Background:The wall of an abdominal aorta aneurysm shows increased activity of metalloproteinases, aspartyl cathepsins and cystein cathepsins, and decreased activity of inhibitors of these enzymes, as compared to the wall of a normal aorta. Parietal thrombi of the aneurysm also show marked proteolytic activity. The aim of our study was to determine the activity of secretory enzymes, membrane enzymes, cytosol enzymes, mitochondrial enzymes and lysosomal enzymes in the blood plasma of patients with abdominal aortic aneurysm.Material/Methods:Blood for examinations was collected from 15 patients with abdominal aorta aneurysm without coexisting diseases, and from the same number of healthy subjects, to determine the activity of lactic acid dehydrogenase (LDH), 5’ nucleotidase (5’NT), gamma-glutamyltranspeptidase (GGTP) and cholinesterase (ChE), alanine aminotransferase (ALT), aspartic aminotransferase (AST), cathepsin B (CB), cathepsin D (CD), and cathepsin L (CL).Results:The plasma activity of ALT, AST and GGTP in the blood of patients with aortic aneurysm is lower than in the plasma of healthy subjects. The activity of LDH, 5’NT and ChE, CB and CL does not significantly differ in the plasma of patients with aortic aneurym compared to the plasma of healthy subjects. The activity of CD is increased in the plasma of patients with aortic aneurysm.Conclusions:Determination of cathepsin D activity may be helpful in the diagnosis of aortic aneurysm.
机译：背景：与正常主动脉壁相比，腹主动脉瘤壁显示出金属蛋白酶，天冬氨酰组织蛋白酶和半胱氨酸组织蛋白酶的活性增加，而这些酶的抑制剂的活性降低。动脉瘤的顶壁血栓也显示出明显的蛋白水解活性。本研究的目的是确定腹主动脉瘤患者血浆中分泌酶，膜酶，细胞溶质酶，线粒体酶和溶酶体酶的活性。材料/方法：从15例腹主动脉瘤患者中采集血液进行检查在不存在并存疾病的情况下，并从相同数目的健康受试者中抽取主动脉瘤，以确定乳酸脱氢酶（LDH），5'核苷酸酶（5'NT），γ-谷氨酰转肽酶（GGTP）和胆碱酯酶（ChE），丙氨酸转氨酶的活性（ALT），天冬氨酸转氨酶（AST），组织蛋白酶B（CB），组织蛋白酶D（CD）和组织蛋白酶L（CL）。结果：主动脉瘤患者血液中ALT，AST和GGTP的血浆活性较低比健康受试者的血浆要高。与健康受试者的血浆相比，主动脉瘤患者血浆中LDH，5'NT和ChE，CB和CL的活性无明显差异。结论：组织蛋白酶D活性的测定可能有助于主动脉瘤的诊断。

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