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Estradiol of effect on the rabbit oviducts morphology with distal tubal occlusion

机译：雌二醇对远端输卵管阻塞的家兔输卵管形态的影响

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Pathological changes in the occluded oviducts depend on the etiology and duration of trauma as well as on the hormonal condition of the patient. The same factors influence the outcome of surgical management. In this study we evaluated the influence of different estradiol (E2) levels on the morphology of oviducts with distal tubal occlusion. The oviducts of sexually mature female rabbits were surgically sutured at their abdominal ends. The animals were allocated into three groups: the first group was castrated; the second received estradiol (E2) (Oestradiol-depot - 0.2 mg/kg q. 7 days - Jenapharm, FRG); and the third remained without further treatment. E2 levels were checked every three weeks by means of the RIA method. Six and 12 weeks following the procedure we performed a salpingectomy. The oviducts were evaluated under light (HE, PAS and staining for reticular fibers), scanning electron and transmission electron microscopes. The castrated animals had an average E2 level of 21.2±6.1 pg/ml, those that received E2 - 845±432 pg/ml, and controls 42.1±12.5 pg/ml. Six weeks following oviduct closure, the castrated animals had wide oviducts with thin and low mucosal folds. Cells had few secretory granules and cilia. The animals receiving E2 had wide folds of tubal mucosa. Ciliated cells had few cilia. Non-castrated animals had secretory granules located in the apical parts of the cell. We also observed some areas deprived of cilia. Twelve months following oviduct closure the most pronounced morphological changes were seen in E2-receiving animals. The tubal lumen was distended, without mucosal folds. The epithelium was low, without cilia. We noted areas without epithelial cells. The oviducts of the castrated animals had a low epithelium, without ciliated cells and no discharge, however mucosal folds were abundant. This study revealed that the low level of E2 delays the onset of abnormalities in oviducts with distal occlusion. Elevated E2 levels amplify these changes.
机译：被阻塞的输卵管的病理变化取决于创伤的病因和持续时间以及患者的荷尔蒙状况。相同的因素影响手术管理的结果。在这项研究中，我们评估了不同雌二醇（E2）水平对输卵管远端输卵管闭塞的形态的影响。在性成熟的雌性兔子的输卵管的腹部末端进行手术缝合。将动物分为三组：第一组被cast割;第二组被cast割。第二次接受雌二醇（E2）（雌二醇储量-0.2 mg / kg，每7天-Jenapharm，FRG）;第三个仍然没有进一步治疗。通过RIA方法每三周检查一次E2水平。手术后六周和十二周，我们进行了输卵管切除术。在光（HE，PAS和网状纤维染色），扫描电子显微镜和透射电子显微镜下评估输卵管。 cast割的动物的平均E2水平为21.2±6.1 pg / ml，接受E2的动物为845±432 pg / ml，对照为42.1±12.5 pg / ml。输卵管闭合后六周，the割的动物的输卵管宽且粘膜褶皱薄且低。细胞几乎没有分泌颗粒和纤毛。接受E2的动物的输卵管粘膜折叠很宽。纤毛细胞纤毛很少。未-割的动物在细胞的顶端有分泌颗粒。我们还观察到一些被剥夺纤毛的地区。输卵管闭合后十二个月，在接受E2的动物中观察到最明显的形态学变化。输卵管腔扩张，无粘膜褶皱。上皮低，无纤毛。我们注意到没有上皮细胞的区域。去势动物的输卵管上皮低，无纤毛细胞，无分泌物，但粘膜褶皱丰富。这项研究表明，低水平的E2会延迟远端闭塞的输卵管的异常发作。 E2水平升高会放大这些变化。

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