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首页> 外文期刊>Medical Sciences >Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction
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Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction

机译：勃起功能障碍对PDE5抑制剂的反应与阴茎双频多普勒超声之间的关系

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The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I ( n = 32), those who responded partially were classified into Group II ( n = 40), and complete responders were classified into Group III ( n = 76). Age, comorbidities, and vascular and penile pathologies were compared among the three groups. While diabetes mellitus (DM) and dyslipidemia positivity adversely affected the response to treatment, the presence of hypertension (HT), Peyronie’s disease and priapism increased the therapeutic response to the treatment ( p 0.05). Arterial insufficiency was present in 20 (30.3%), 25 (37.9%) and 21 (31.8%) of the patients in Group I, Group II and Group III, respectively ( p = 0.001). Venous insufficiency was observed in three (14.3%) patients in Group I and in eight (85.7%) patients in Group III ( p = 0.001). Arterial/venous insufficiency was seen in 9 (30%), 14 (46.7%) and 7 (23.3%) of the patients in Group I, Group II and Group III, respectively ( p = 0.001). The response rate to treatment was highest in normal patients according to PDDU, followed by patients with venous insufficiency. In addition, it was found that DM decreased the response to treatment, whereas the response increased in cases with HT, priapism and Peyronie’s disease.
机译：在诊断为勃起功能障碍（ED）的患者中研究了阴茎双工多普勒超声（PDDU）结果与对伐地那非反应之间的关系。回顾性分析了148例ED患者的数据。对治疗无反应的患者分为I组（n = 32），对部分治疗无反应的患者分为II组（n = 40），完全反应的患者分为III组（n = 76）。比较了三组的年龄，合并症，血管和阴茎病变。糖尿病（DM）和血脂异常对治疗反应有不利影响，而高血压（HT），佩罗尼氏病和阴茎异常勃起的存在增加了对治疗的治疗反应（p <0.05）。 I组，II组和III组分别有20位（30.3％），25位（37.9％）和21位（31.8％）的患者出现动脉功能不全（p = 0.001）。在第一组中三名（14.3％）患者和第三组中八名（85.7％）患者中观察到静脉功能不全（p = 0.001）。第一组，第二组和第三组分别有9（30％），14（46.7％）和7（23.3％）的患者出现了动脉/静脉功能不全（p = 0.001）。根据PDDU，正常患者对治疗的反应率最高，其次是静脉功能不全的患者。此外，还发现DM降低了对治疗的反应，而在HT，阴茎异常勃勃和Peyronie病患者中，反应增加了。

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