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Narcolepsy and Psychiatric Disorders: Comorbidities or Shared Pathophysiology?

机译：发作性睡病和精神疾病：合并症或共同的病理生理学？

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Narcolepsy and psychiatric disorders have a significant but unrecognized relationship, which is an area of evolving interest, but unfortunately, the association is poorly understood. It is not uncommon for the two to occur co-morbidly. However, narcolepsy is frequently misdiagnosed initially as a psychiatric condition, contributing to the protracted time to accurate diagnosis and treatment. Narcolepsy is a disabling neurodegenerative condition that carries a high risk for development of social and occupational dysfunction. Deterioration in function may lead to the secondary development of psychiatric symptoms. Inversely, the development of psychiatric symptoms can lead to the deterioration in function and quality of life. The overlap in pharmaceutical intervention may further enhance the difficulty to distinguish between diagnoses. Comprehensive care for patients with narcolepsy should include surveillance for psychiatric illness and appropriate treatment when necessary. Further research is necessary to better understand the underlying pathophysiology between psychiatric disease and narcolepsy.
机译：发作性睡病和精神疾病具有重要但尚未被认识的关系，这是一个不断发展的兴趣领域，但是不幸的是，这种关联还知之甚少。两者并存的情况并不少见。然而，发作性睡病最初常常被误诊为精神病，导致长时间无法准确诊断和治疗。发作性睡病是一种致残性神经退行性疾病，对社交和职业功能障碍的发展具有很高的风险。功能恶化可能导致精神症状的继发性发展。相反，精神症状的发展会导致功能和生活质量下降。药物干预的重叠可能会进一步增加区分诊断的难度。对发作性睡病患者的全面护理应包括对精神病的监测以及必要时的适当治疗。为了更好地了解精神病和发作性睡病之间的潜在病理生理，有必要进行进一步的研究。

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