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首页> 外文期刊>Medical Science Monitor Basic Research >Differential effects of selective and non-selective nitric oxide synthase inhibitors on the blood perfusion of ischemia-reperfused myocardium in dogs
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Differential effects of selective and non-selective nitric oxide synthase inhibitors on the blood perfusion of ischemia-reperfused myocardium in dogs

机译：选择性和非选择性一氧化氮合酶抑制剂对犬缺血再灌注心肌血流灌注的不同作用

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Background Nitric oxide (NO) is protective for the cardiovascular system, and excessive NO exerts negative effects on the circulatory system. This study aimed to compare the effects of selective or non-selective NO synthase (NOS) inhibitors on blood flow perfusion of ischemia-reperfused myocardium. Material and Methods Male mongrel dogs were randomly assigned to 4 groups: only ischemia-reperfusion (control), ischemia-reperfusion plus Nù-nitro-L-arginine methyl ester (NAME) treatment, ischemia-reperfusion plus aminoguanidine (AMD) treatment, and sham operation group. Myocardial contrast echocardiography (MCE) was performed. Blood samples were taken for measurement of NO. Background-subtracted peak videointensity (PVI) and PVI ratio in myocardium were measured. Results In the NAME-treated group, the PVI at 5 min reperfusion did not significantly differ from pre-LAD-occlusion, but declined to and retained at a level obviously lower than the pre-LAD-occlusion. In the AMD-treated group, the PVI at 5 min reperfusion was significantly higher than at pre-LAD-occlusion, and then restored to and remained at the pre-LAD-occlusion level. The changes of PVI ratios in the 3 groups were similar to PVI values. In the AMD-treated group, the curve width increased in the early reperfusion, but returned to the pre-LAD-occlusion level at 90 min reperfusion. The plasma NO concentration in the NAME-treated group greatly decreased and remained low during the whole period of reperfusion. In the AMD-treated group, there were only slight increases in NO concentrations during reperfusion. Conclusions NAME totally inhibited NO production and attenuated myocardial blood flow perfusion. Aminoguanidine significantly relieved the increase in NO production and alleviated the congestion of reperfused myocardium. Selective inhibitors of iNOS might be useful in the management of certain diseases associated with ischemia-reperfusion.
机译：背景一氧化氮（NO）对心血管系统具有保护作用，过量的NO对循环系统产生不利影响。这项研究旨在比较选择性或非选择性NO合酶（NOS）抑制剂对缺血再灌注心肌血流灌注的影响。材料和方法将雄性杂种犬随机分为4组：仅缺血再灌注（对照组），缺血再灌注加Nù-硝基-L-精氨酸甲酯（NAME）治疗，缺血再灌注加氨基胍（AMD）治疗和假手术组。进行心肌对比超声心动图（MCE）。采集血样以测量NO。测量背景减去心肌的峰值视频强度（PVI）和PVI比率。结果在NAME治疗组中，再灌注5分钟时的PVI与LAD闭塞前无显着差异，但下降至并保持在明显低于LAD闭塞前的水平。在AMD治疗组中，再灌注5分钟时的PVI明显高于LAD闭塞前的水平，然后恢复到LAD闭塞前的水平并保持在该水平。 3组的PVI比值变化与PVI值相似。在AMD治疗组中，曲线的宽度在早期再灌注时增加，但在90分钟再灌注时恢复到LAD闭塞前的水平。在整个再灌注期间，NAME治疗组的血浆NO浓度大大降低，并保持较低水平。在AMD治疗组中，再灌注期间NO浓度仅略有增加。结论NAME完全抑制NO生成，并减弱心肌血流灌注。氨基胍显着减轻了NO产生的增加，减轻了再灌注心肌的充血。 iNOS的选择性抑制剂可能在某些与缺血再灌注有关的疾病的治疗中有用。

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