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首页> 外文期刊>Medical Science Monitor Basic Research >Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice
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Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice

机译：西地那非可增强幼鼠的运动能力，并在幼鼠和老年鼠中发挥抗焦虑作用

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Background Sildenafil is a selective PDE5 inhibitor that increases cGMP levels in the target tissues and is an effective treatment agent for erectile dysfunction. The nitric oxide-cGMP pathway might be implicated in regulation of certain CNS functions, including locomotor activity and anxiety. Material and Methods The aim of the current study was to investigate effects of sildenafil (3 and 10 mg/kg) on anxiety and locomotor activity in open field and elevated plus maze (EPM) tests in young and aged mice. Results Sildenafil (3 and 10 mg/kg) significantly decreased the percent of time spent in the open arms compared to the control group in young animals in the EPM test, but only the 10 mg/kg dose significantly decreased the percentage of total number of entries to the open arms in young animals. Sildenafil (3 and 10 mg/kg) significantly decreased the percentage of total number of entries to the open arms in aged animals in the EPM test, but it significantly increased total distance moved and speed of the animals in the locomotor activity test in young animals. The total distance moved and the speed of the animals significantly decreased in aged animals compared to the young control group, although sildenafil (3 and 10 mg/kg) did not alter these parameters in aged mice. Conclusions Our results show that sildenafil had anxiogenic effects in young as well as aged mice, but it enhanced locomotor activity only in the young mice in the EPM test. Thus, sildenafil seems to exert different effects on anxiety and locomotion in young and aged animals.
机译：背景西地那非是一种选择性的PDE5抑制剂，可增加靶组织中的cGMP水平，并且是勃起功能障碍的有效治疗剂。一氧化氮-cGMP途径可能与某些中枢神经系统功能的调节有关，包括运动活动和焦虑。材料和方法本研究的目的是研究西地那非（3和10 mg / kg）对幼年和老年小鼠在旷野和高架迷宫试验中的焦虑和运动能力的影响。结果在EPM试验中，与对照组相比，西地那非（3和10 mg / kg）显着减少了在对照组中张开双臂所花费的时间百分比，但只有10 mg / kg的剂量显着降低了张开双臂的总百分比小动物张开双臂的入口。西地那非（3和10 mg / kg）在EPM测试中显着降低了成年动物张开双臂的总进入次数的百分比，但是在幼年动物的运动活动测试中，其显着增加了动物的总移动距离和速度。与老年对照组相比，老年动物的总移动距离和动物速度显着降低，尽管昔多芬（3和10 mg / kg）并未改变老年小鼠的这些参数。结论我们的结果表明，西地那非对幼年和老年小鼠均具有促焦虑作用，但在EPM试验中，西地那非仅能增强幼年小鼠的运动能力。因此，西地那非似乎对年轻和老年动物的焦虑和运动产生不同的影响。

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