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Improvement of biohistological response of facial implant materials by tantalum surface treatment

机译：钽表面处理改善面部植入物材料的生物组织学反应

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Abstract BackgroundA compact passive oxide layer can grow on tantalum (Ta). It has been reported that this oxide layer can facilitate bone ingrowth in vivo though the development of bone-like apatite, which promotes hard and soft tissue adhesion. Thus, Ta surface treatment on facial implant materials may improve the tissue response, which could result in less fibrotic encapsulation and make the implant more stable on the bone surface. The purposes of this study were to verify whether surface treatment of facial implant materials using Ta can improve the biohistobiological response and to determine the possibility of potential clinical applications.MethodsTwo different and commonly used implant materials, silicone and expanded polytetrafluoroethylene (ePTFE), were treated via Ta ion implantation using a Ta sputtering gun. Ta-treated samples were compared with untreated samples using in vitro and in vivo evaluations. Osteoblast (MG-63) and fibroblast (NIH3T3) cell viability with the Ta-treated implant material was assessed, and the tissue response was observed by placing the implants over the rat calvarium ( n =?48) for two different lengths of time. Foreign body and inflammatory reactions were observed, and soft tissue thickness between the calvarium and the implant as well as the bone response was measured.ResultsThe treatment of facial implant materials using Ta showed a tendency toward increased fibroblast and osteoblast viability, although this result was not statistically significant. During the in vivo study, both Ta-treated and untreated implants showed similar foreign body reactions. However, the Ta-treated implant materials (silicone and ePTFE) showed a tendency toward better histological features: lower soft tissue thickness between the implant and the underlying calvarium as well as an increase in new bone activity.ConclusionTa surface treatment using ion implantation on silicone and ePTFE facial implant materials showed the possibility of reducing soft tissue intervention between the calvarium and the implant to make the implant more stable on the bone surface. Although no statistically significant improvement was observed, Ta treatment revealed a tendency toward an improved biohistological response of silicone and ePTFE facial implants. Conclusively, tantalum treatment is beneficial and has the potential for clinical applications.
机译：摘要背景致密的钝化氧化物层可以在钽（Ta）上生长。据报道，该氧化物层通过骨状磷灰石的发展可以促进体内骨骼的向内生长，从而促进了硬组织和软组织的粘附。因此，对面部植入物材料进行Ta表面处理可以改善组织反应，这可能导致较少的纤维化包囊，并使植入物在骨表面上更稳定。这项研究的目的是验证使用Ta对面部植入物材料进行表面处理是否可以改善生物组织生物学反应，并确定潜在的临床应用的可能性。方法对两种不同且常用的植入物材料（硅树脂和膨体聚四氟乙烯（ePTFE））进行了处理通过使用Ta溅射枪进行Ta离子注入。使用体外和体内评估将Ta处理的样品与未处理的样品进行比较。用Ta处理过的植入物评估成骨细胞（MG-63）和成纤维细胞（NIH3T3）的细胞活力，并将植入物放在大鼠颅骨上（n =？48）两种不同的时间长度，观察组织反应。观察到异物和炎症反应，并测量了颅骨和植入物之间的软组织厚度以及骨骼反应。结果使用Ta处理面部植入物材料有增加成纤维细胞和成骨细胞活力的趋势，尽管这一结果并非如此。具有统计意义。在体内研究期间，经Ta处理的植入物和未经处理的植入物均表现出相似的异物反应。但是，经过Ta处理的植入物材料（有机硅和ePTFE）显示出趋向于更好的组织学特征的趋势：植入物与下面的颅骨之间的软组织厚度降低，并且新骨活性增加。和ePTFE面部植入物材料显示出减少颅骨和植入物之间的软组织干预的可能性，从而使植入物在骨表面上更稳定。尽管未观察到统计学上的显着改善，但Ta治疗显示出有机硅和ePTFE面部植入物的生物组织学反应有所改善的趋势。总之，钽治疗是有益的，并且具有临床应用潜力。

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