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Hyperbaric oxygen therapy for traumatic brain injury

机译：高压氧治疗脑外伤

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Traumatic brain injury (TBI) is a major public health issue. The complexity of TBI has precluded the use of effective therapies. Hyperbaric oxygen therapy (HBOT) has been shown to be neuroprotective in multiple neurological disorders, but its efficacy in the management of TBI remains controversial. This review focuses on HBOT applications within the context of experimental and clinical TBI. We also discuss its potential neuroprotective mechanisms. Early or delayed multiple sessions of low atmospheric pressure HBOT can reduce intracranial pressure, improve mortality, as well as promote neurobehavioral recovery. The complimentary, synergistic actions of HBOT include improved tissue oxygenation and cellular metabolism, anti-apoptotic, and anti-inflammatory mechanisms. Thus HBOT may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes.
机译：颅脑外伤（TBI）是主要的公共卫生问题。 TBI的复杂性排除了有效疗法的使用。高压氧疗法（HBOT）已被证明在多种神经系统疾病中具有神经保护作用，但其在TBI管理中的疗效仍存在争议。这篇综述着重于在实验和临床TBI背景下的HBOT应用。我们还讨论了其潜在的神经保护机制。低气压HBOT的早期或延迟多个疗程可降低颅内压，提高死亡率，并促进神经行为恢复。 HBOT的互补，协同作用包括改善组织的氧合作用和细胞代谢，抗凋亡和抗炎机制。因此，HBOT可以作为一种有前途的神经保护策略，与TBI患者的其他治疗靶点结合使用时，可以改善长期预后。

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