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首页> 外文期刊>Medical Gas Research >Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model
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Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model

机译：氢盐水通过减轻局灶性脑缺血再灌注大鼠模型的氧化应激来提供神经保护作用

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摘要

Hydrogen gas is neuroprotective in cerebral ischemia animal models. In this study, we tested the neuroprotective effects of hydrogen saline, which is safe and easy to use clinically, in a rat model of middle cerebral artery occlusion (MCAO). Sprague-Dawley male rats weighting 250-280 g were divided into sham, MCAO plus hydrogen saline and MCAO groups, and subjected to 90-min ischemia followed by 24 h of reperfusion. Hydrogen saline was injected intraperitoneally at 1 ml/100 g body weight. Infarct volume and brain water content were evaluated at different time points after reperfusion. Oxidative stress, inflammation, and apoptotic cell death markers were measured. Hydrogen saline significantly reduced the infarct volume and edema and improved the neurological function, when it was administered at 0, 3 and 6 h after reperfusion. Hydrogen saline decreased 8-hydroxyl-2'-deoxyguanosine (8-OHdG), reduced malondidehyde, interleukin-1β, tumor necrosis factor-α, and suppressed caspase 3 activity in the ischemic brain. These findings demonstrated hydrogen saline is neuroprotective when administered within 6 h after ischemia. Because hydrogen saline is safe and easy to use, it has clinical potentials to reduce neurological injuries.
机译：氢气在脑缺血动物模型中具有神经保护作用。在这项研究中，我们在大脑中动脉闭塞（MCAO）的大鼠模型中测试了安全，易于临床使用的氢盐水的神经保护作用。将重量为250-280 g的Sprague-Dawley雄性大鼠分为假手术，MCAO加氢盐水和MCAO组，进行90分钟的缺血，然后再灌注24 h。以1ml / 100g体重腹膜内注射盐水。在再灌注后的不同时间点评估梗塞体积和脑含水量。测量了氧化应激，炎症和凋亡细胞死亡标志物。当在再灌注后0、3和6 h给予生理盐水时，生理盐水可显着减少梗塞体积和水肿并改善神经功能。氢盐水可降低缺血性脑中的8-羟基-2'-脱氧鸟苷（8-OHdG），丙二醛，白介素-1β，肿瘤坏死因子-α并抑制caspase 3活性。这些发现表明，在缺血后6小时内给予氢盐水具有神经保护作用。由于氢盐水安全且易于使用，因此具有减少神经损伤的临床潜力。

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