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首页> 外文期刊>Medical Gas Research >Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats
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Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats

机译：一氧化碳气体对结肠的吹入会抑制大鼠肠道炎症的发展

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Background The pathogenesis of inflammatory bowel disease (IBD) is complex, and an effective therapeutic strategy has yet to be established. Recently, carbon monoxide (CO) has been reported to be capable of reducing inflammation by multiple mechanisms. In this study, we evaluated the role of colonic CO insufflation in acute colitis induced by trinitrobenzene sulfonic acid (TNBS) in rats. Methods Acute colitis was induced with TNBS in male Wistar rats. Following TNBS administration, the animals were treated daily with 200?ppm of intrarectal CO gas. The distal colon was removed to evaluate various parameters of inflammation, including thiobarbituric acid (TBA)-reactive substances, tissue-associated myeloperoxidase (MPO) activity, and the expression of cytokine-induced neutrophil chemoattractant (CINC)-1 in colonic mucosa 7?days after TNBS administration. Results The administration of TNBS induced ulceration with surrounding edematous swelling in the colon. In rats treated with CO gas, the colonic ulcer area was smaller than that of air-treated rats 7?days after TNBS administration. The wet colon weight was significantly increased in the TNBS-induced colitis group, which was markedly abrogated by colonic insufflation with CO gas. The increase of MPO activity, TBA-reactive substances, and CINC-1 expression in colonic mucosa were also significantly inhibited by colonic insufflation with CO gas. Conclusions Colonic insufflation with CO gas significantly ameliorated TNBS-induced colitis in rats. Clinical application of CO gas to improve colonic inflammatory conditions such as IBD might be useful.
机译：背景技术炎症性肠病（IBD）的发病机制很复杂，有效的治疗策略尚未确立。最近，据报道一氧化碳（CO）能够通过多种机制减轻炎症。在这项研究中，我们评估了结肠CO吹入在三硝基苯磺酸（TNBS）诱导的大鼠急性结肠炎中的作用。方法TNBS诱导雄性Wistar大鼠急性结肠炎。 TNBS给药后，每天用200？ppm的直肠内CO气体治疗动物。切除远端结肠以评估各种炎症参数，包括硫代巴比妥酸（TBA）反应性物质，组织相关性髓过氧化物酶（MPO）活性以及细胞因子诱导的中性粒细胞趋化因子（CINC）-1在结肠粘膜中的表达7。 TNBS管理后的几天。结果TNBS引起的溃疡性溃疡伴结肠周围水肿。在用TNBS给药7天后，用CO气体处理的大鼠的结肠溃疡面积小于空气处理的大鼠。在TNBS诱导的结肠炎组中，湿结肠重量显着增加，由于用CO气体进行结肠吹入而明显消除了结肠炎。 CO气体对结肠的吹入也显着抑制了结肠黏膜中MPO活性，TBA反应性物质和CINC-1表达的增加。结论CO 2气体结肠吹入可明显改善TNBS所致大鼠结肠炎。临床上使用CO气体改善结肠炎症性疾病（如IBD）可能会有用。

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