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首页> 外文期刊>Medical Gas Research >Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
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Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

机译：一项开放性试验研究表明，消耗高浓度分子氢的水可减少类风湿关节炎患者的氧化应激和疾病活动

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Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extremely high concentration of H2 has been developed. We hypothesized that H2 in the water could complement conventional therapy by reducing the oxidative stress in RA. Methods Twenty patients with rheumatoid arthritis (RA) drank 530?ml of water containing 4 to 5?ppm molecular hydrogen (high H2 water) every day for 4?weeks. After a 4-week wash-out period, the patients drank the high H2 water for another 4?weeks. Urinary 8-hydroxydeoxyguanine (8-OHdG) and disease activity (DAS28, using C-reactive protein [CRP] levels) was estimated at the end of each 4-week period. Results Drinking high H2 water seems to raise the concentration of H2 more than the H2 saturated (1.6?ppm) water in vivo. Urinary 8-OHdG was significantly reduced by 14.3% (p? Conclusions The results suggest that the hydroxyl radical scavenger H2 effectively reduces oxidative stress in patients with this condition. The symptoms of RA were significantly improved with high H2 water.
机译：背景类风湿关节炎（RA）是一种慢性炎症性疾病，其特征在于骨骼和软骨的破坏。尽管其病因尚不清楚，但已暗示羟基自由基与RA的发病机理有关。最近，分子氢（H 2 ）被证明是羟基自由基的选择性清除剂。而且，已经开发了制备含有极高浓度的H 2 的水的方法。我们假设水中的H 2 可以通过减少RA的氧化应激来补充常规疗法。方法20名风湿性关节炎（RA）患者每天饮用530毫升水，其中含有4至5 ppm ppm的分子氢（高H 2 水），持续4周。经过4周的冲洗后，患者再喝高H 2 水4周。在每4周结束时估算尿中的8-羟基脱氧鸟嘌呤（8-OHdG）和疾病活性（DAS28，使用C反应蛋白[CRP]水平）。结果体内高浓度的H 2 水似乎比体内H 2 饱和水（1.6？ppm）升高了H 2 浓度。结论尿中的8-OHdG显着降低了14.3％（p？结论）结果表明，羟自由基清除剂H 2 有效地减轻了这种情况下的氧化应激。 H 2 水。

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