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首页> 外文期刊>Medical Gas Research >Are volatile anesthetics neuroprotective or neurotoxic?
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Are volatile anesthetics neuroprotective or neurotoxic?

机译：挥发性麻醉药对神经有保护作用还是对神经有毒作用？

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Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other effects of these anesthetics on the central nervous system, volatile anesthetics-induced neuroprotection and neurotoxicity, currently are hot research fields. Although data from animal studies for these two effects are extensive and convincing, clinical data for volatile anesthetics-induced neuroprotection are relatively weak. There is essentially lack of evidence to suggest volatile anesthetics-induced neurotoxicity in humans. In this regard, the contribution of general anesthesia/anesthetics to postoperative cognitive decline, a clinical entity whose existence has been supported by substantial evidence, also has not been established. This paper will be focused on reviewing the evidence, especially the clinical evidence, for volatile anesthetics-induced neuroprotection and neurotoxicity. Efforts will be devoted to facilitating the understanding of the two seemingly contradictory effects of these important drugs on the brain.
机译：挥发性麻醉剂是一类最常用的药物。但是，这些药物诱导麻醉的机制尚未完全了解，并且已经进行了深入研究。这些麻醉剂对中枢神经系统的另外两个影响，即挥发性麻醉剂引起的神经保护和神经毒性，目前是热门的研究领域。尽管来自动物研究的关于这两种作用的数据广泛且令人信服，但挥发性麻醉药诱导的神经保护作用的临床数据相对较弱。基本上没有证据表明挥发性麻醉药可引起人体神经毒性。在这方面，还没有确定全身麻醉/麻醉药对术后认知功能减退的贡献，后者是其存在得到大量证据支持的临床实体。本文将重点回顾挥发性麻醉药引起的神经保护和神经毒性的证据，尤其是临床证据。将致力于促进对这些重要药物对大脑的两种看似矛盾的作用的理解。

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