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首页> 外文期刊>Medicine. >Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China: A cohort study in the Zhuang population
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Genetic polymorphisms in very important pharmacogenomic variants in the Zhuang ethnic group of Southwestern China: A cohort study in the Zhuang population

机译：中国西南壮族非常重要的药物基因组学变异中的遗传多态性：一项针对壮族的队列研究

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Pharmacogenomics , the study of the role of genetics in drug response, has recently become a focal point of research. Previous studies showed that genes associated with drug detoxification vary among different populations. However, pharmacogenomic information of the Zhuang ethnic group is scarce. The aim of the present study was to screen members of the Zhuang ethnicity in southwestern China for genotype frequencies of very important pharmacogenomic (VIP) variants and to determine the differences between the Zhuang ethnicity and other human populations. We genotyped 80 variants of VIP genes in 100 unrelated healthy Zhuang adults from the Yunnan province of China. Next, we analyzed the genotyping data with Structure and F -statistics ( F st). We compared our data with those of other populations using the HapMap data set, and observed that the frequency distribution of Zhuang population in Yunnan closely resembles that of JPT. Furthermore, population structure and F st analysis showed that the Zhuang population is closely related to the Shaanxi Han population with respect to genetic background. Our study supplements existing information on Zhuang population pharmacogenomics and provides an extensive overview for developing personalized medicine.
机译：药物基因组学是遗传学在药物反应中作用的研究，最近已成为研究的重点。先前的研究表明，与毒品解毒相关的基因在不同人群中有所不同。但是，壮族的药物基因组学信息很少。本研究的目的是筛选中国西南壮族成员中非常重要的药物基因组学（VIP）变异的基因型频率，并确定壮族与其他人群之间的差异。我们对来自中国云南省的100名无亲属的健康壮族成年人的VIP基因进行了80个基因分型。接下来，我们使用结构和F统计量（F st ）对基因分型数据进行了分析。我们使用HapMap数据集将我们的数据与其他人群的数据进行了比较，并观察到云南壮族的频率分布与JPT极为相似。此外，人口结构和F st 分析表明，就壮族而言，壮族与陕西汉族紧密相关。遗传背景。我们的研究补充了有关壮族药物基因组学的现有信息，并为开发个性化药物提供了广泛的概述。

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